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Emerging Microbes & Infections Volume 10, 2021 - Issue 1
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Enterovirus 71 (EV71)

A single mutation in the cis-acting replication element identified within the EV-A71 2C-coding region causes defects in virus production in cell culture

Juemin Xia Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, People’s Republic of ChinaView further author information
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Chunxia Maa Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, People’s Republic of ChinaView further author information
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Zhizhong Weib The State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
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Bin Yinb The State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
,
Siwen Zhaoa Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, People’s Republic of ChinaView further author information
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Wenqi Quana Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, People’s Republic of ChinaView further author information
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Jing Yanga Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, People’s Republic of ChinaView further author information
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Jiangang Yuanb The State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
,
Boqin Qiangb The State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
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Fei Yeb The State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China;c NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, People’s Republic of ChinaView further author information
&
Xiaozhong Penga Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, People’s Republic of China;b The State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence[email protected]
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Pages 1988-1999 | Received 06 Jul 2021, Accepted 02 Sep 2021, Published online: 17 Oct 2021

Figures & data

Figure 1. Recognition of the cre in the EV-A71 genome.

Figure 1. Recognition of the cre in the EV-A71 genome.

Figure 2. Effects of the cre on EV-A71 replication based on EV-A71 replicons.

Figure 2. Effects of the cre on EV-A71 replication based on EV-A71 replicons.

Figure 3. Effects of the cre on EV-A71 replication based on full-length cDNA constructs.

Figure 3. Effects of the cre on EV-A71 replication based on full-length cDNA constructs.

Figure 4. Interaction between the EV-A71-cre RNA and cellular proteins.

Figure 4. Interaction between the EV-A71-cre RNA and cellular proteins.
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