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Emerging Microbes & Infections Volume 11, 2022 - Issue 1
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Influenza infections

Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021

Alexander Postela Institute of Virology, University of Veterinary Medicine, Hannover, GermanyORCID Iconhttps://orcid.org/0000-0002-1187-1069View further author information
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Jacqueline Kingb Institute of Diagnostic Virology, Friedrich-Loeffler-Institute, Greifswald, GermanyORCID Iconhttps://orcid.org/0000-0003-1857-7660View further author information
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Franziska K. Kaiserc Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, GermanyORCID Iconhttps://orcid.org/0000-0002-7758-9605View further author information
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Johanna Kennedya Institute of Virology, University of Veterinary Medicine, Hannover, GermanyView further author information
,
Mara Sophie Lombardod Institute of Pathology, University of Veterinary Medicine, Hannover, GermanyView further author information
,
Wencke Reinekingd Institute of Pathology, University of Veterinary Medicine, Hannover, GermanyORCID Iconhttps://orcid.org/0000-0002-8223-7233View further author information
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Madeleine de le Roid Institute of Pathology, University of Veterinary Medicine, Hannover, GermanyORCID Iconhttps://orcid.org/0000-0002-7799-9399View further author information
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Timm Harderb Institute of Diagnostic Virology, Friedrich-Loeffler-Institute, Greifswald, GermanyORCID Iconhttps://orcid.org/0000-0003-2387-378XView further author information
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Anne Pohlmannb Institute of Diagnostic Virology, Friedrich-Loeffler-Institute, Greifswald, GermanyORCID Iconhttps://orcid.org/0000-0002-5318-665XView further author information
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Thomas Gerlachc Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, GermanyView further author information
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Guus Rimmelzwaanc Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, GermanyORCID Iconhttps://orcid.org/0000-0002-1921-4581View further author information
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Simon Rohnere Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine, Hannover, GermanyORCID Iconhttps://orcid.org/0000-0002-8254-0128View further author information
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Lotte C. Striewee Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine, Hannover, GermanyORCID Iconhttps://orcid.org/0000-0001-8859-2597View further author information
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Stephanie Grosse Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine, Hannover, GermanyORCID Iconhttps://orcid.org/0000-0002-7734-1466View further author information
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Luca A. Schicke Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine, Hannover, GermanyORCID Iconhttps://orcid.org/0000-0001-5755-0861View further author information
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Jana C. Klinke Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine, Hannover, GermanyORCID Iconhttps://orcid.org/0000-0002-5347-0407View further author information
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Katharina Kramerf Landeslabor Schleswig- Holstein, Neumünster, GermanyView further author information
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Albert D. M. E. Osterhausc Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, GermanyORCID Iconhttps://orcid.org/0000-0001-6535-3497View further author information
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Martin Beerb Institute of Diagnostic Virology, Friedrich-Loeffler-Institute, Greifswald, GermanyORCID Iconhttps://orcid.org/0000-0002-0598-5254View further author information
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Wolfgang Baumgärtnerd Institute of Pathology, University of Veterinary Medicine, Hannover, GermanyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8151-5644View further author information
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Ursula Sieberte Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine, Hannover, GermanyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2556-3948View further author information
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Paul Bechera Institute of Virology, University of Veterinary Medicine, Hannover, GermanyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7857-1354View further author information
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Pages 725-729 | Received 16 Nov 2021, Accepted 14 Feb 2022, Published online: 01 Mar 2022

Figures & data

Figure 1. Phylogenetic analysis of hemagglutinin (HA) encoding sequences of highly pathogenic avian influenza viruses (HPAIV) subtype H5N8. (A) Complete H5 encoding nucleotide sequences obtained from brain tissues of three seals determined within this study (indicated in bold) were compared to sequences of H5N8 HPAIV previously detected in seals from Poland (2016), England (2020) and a human case (2020) from Russia [Citation4,Citation7,Citation14]. In addition, a representative set of H5 sequences affiliated to clade 2.3.4.4b is included. Sequences were obtained from the EpiFluTM GISAID database and accession numbers are indicated next to the cryptograms [Citation15]. Phylogeny was performed using a maximum likelihood approach implemented in MegaX (best fit model: HKY + G). Numbers at nodes represent bootstrap values of 70 or higher. Scale bar indicates nucleotide substitutions per site. (B) Variant amino acids in the HA, PA, PB1 and PB2 proteins are shown for selected sequences (indicated by * in the phylogenetic tree, panel A), respectively. Positions of amino acid substitutions implicated in adaptation to mammalian hosts are given in the top row.

Figure 1. Phylogenetic analysis of hemagglutinin (HA) encoding sequences of highly pathogenic avian influenza viruses (HPAIV) subtype H5N8. (A) Complete H5 encoding nucleotide sequences obtained from brain tissues of three seals determined within this study (indicated in bold) were compared to sequences of H5N8 HPAIV previously detected in seals from Poland (2016), England (2020) and a human case (2020) from Russia [Citation4,Citation7,Citation14]. In addition, a representative set of H5 sequences affiliated to clade 2.3.4.4b is included. Sequences were obtained from the EpiFluTM GISAID database and accession numbers are indicated next to the cryptograms [Citation15]. Phylogeny was performed using a maximum likelihood approach implemented in MegaX (best fit model: HKY + G). Numbers at nodes represent bootstrap values of 70 or higher. Scale bar indicates nucleotide substitutions per site. (B) Variant amino acids in the HA, PA, PB1 and PB2 proteins are shown for selected sequences (indicated by * in the phylogenetic tree, panel A), respectively. Positions of amino acid substitutions implicated in adaptation to mammalian hosts are given in the top row.
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Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021
Source: Taylor & Francis

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