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Emerging Microbes & Infections Volume 11, 2022 - Issue 1
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Coronaviruses

Reduced neutralization of SARS-CoV-2 Omicron variant by BNT162b2 vaccinees’ sera: a preliminary evaluation

D. Miletoa Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9414-0287
ORCID Icon,
V. Michelia Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy
,
C. Feniziab Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Milan, Italy;c Department of Pathophysiology and Transplantation, University of Milan, Milan, ItalyORCID Iconhttps://orcid.org/0000-0003-0735-8331
ORCID Icon,
M. Cutreraa Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy
,
G. Gagliardia Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy
,
A. Mancona Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, ItalyORCID Iconhttps://orcid.org/0000-0002-1490-636X
ORCID Icon,
F. Bracchittaa Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy
,
A. De Silvestrid Clinical Epidemiology and Biometeric Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
,
G. Rizzardinie Division of Infectious Diseases, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, ItalyORCID Iconhttps://orcid.org/0000-0002-5183-7818
ORCID Icon,
A. Lombardia Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy
,
M. Biasinb Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Milan, Italy
&
M. R. Gismondoa Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy
 show all
Pages 790-792 | Received 13 Jan 2022, Accepted 19 Feb 2022, Published online: 10 Mar 2022

Figures & data

Figure 1. SARS-CoV-2 variants of concern (VOC). Panel (A) Neutralization assay (NTA) performed on the SARS-CoV-2 lineage B.1 (EU) and 2 VOCs, d and o. Panels B and C comparison between the Omicron variant and the EU and delta variant, respectively. Lines connect the NTAs of each individual subject. Panel D shows the correlation between anti-SARS-CoV-2 specific antibodies and neutralization assays (NTA) measured 1 month post two doses of the BNT162b2 vaccine. Three weeks after a third dose both antibody titres (Panel E) and neutralizing activity (NA) (Panel F) increased. **** = p <0.0001.

Figure 1. SARS-CoV-2 variants of concern (VOC). Panel (A) Neutralization assay (NTA) performed on the SARS-CoV-2 lineage B.1 (EU) and 2 VOCs, d and o. Panels B and C comparison between the Omicron variant and the EU and delta variant, respectively. Lines connect the NTAs of each individual subject. Panel D shows the correlation between anti-SARS-CoV-2 specific antibodies and neutralization assays (NTA) measured 1 month post two doses of the BNT162b2 vaccine. Three weeks after a third dose both antibody titres (Panel E) and neutralizing activity (NA) (Panel F) increased. **** = p <0.0001.

Data availability statement

The data that support the findings of this study are available from the corresponding author, D.M., upon reasonable request.

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