https://orcid.org/0000-0001-5488-5068
Figures & data
Figure 1. Preferred reporting items for systematic reviews and meta-analyses (PRISMA) study flowchart.
Table 1. Baseline study characteristics of published randomized controlled trials of IL-6 receptor antagonist [Citation15–30].
Table 2. GRADE summary of findings table of mortality, progression to invasive mechanical ventilation, and serious adverse events.
Figure 2. Forest plot of all-cause 28-day mortality. Forest plot showing the risk ratio in mortality between patients treated with IL-6 receptor antagonist compared with standard of care (SOC). Meta-analysis on 17 randomized controlled studies comprising 8455 patients showed that mortality was significantly 11% lower for patients with COVID-19 treated with tocilizumab compared to SOC and not significant but with lowering 19% mortality in patients treated with sarilumab. Abbreviations: CI, confidence interval; M-H, Mantel-Haenszel random-effects; SOC, standard of care.
Figure 3. Forest plot of progression to invasive mechanical ventilation. Forest plot showing the risk ratio in progression to invasive mechanical ventilation (IMV) between patients treated with tocilizumab compared with standard of care (SOC). Meta-analysis on 9 randomized controlled studies comprising 5507 patients showed that progression to IMV was significantly 21% lower for patients with COVID-19 treated with tocilizumab compared to SOC, and not significantly different in patients treated with sarilumab. Abbreviations: CI, confidence interval; M-H, Mantel-Haenszel random-effects; SOC, standard of care; IMV, invasive mechanical ventilation.
Figure 4. Forest plot of serious adverse events. Forest plot showing the risk ratio in serious adverse events between patients treated with IL-6 receptor antagonist compared with standard of care (SOC). Meta-analysis on 15 randomized controlled studies comprising 3952 patients showed that serious adverse events was significantly 17% lower for patients with COVID-19 treated with tocilizumab compared to SOC and not significant in patients treated with sarilumab. Abbreviations: CI, confidence interval; M-H, Mantel-Haenszel random-effects; SOC, standard of care.
