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Emerging Microbes & Infections Volume 11, 2022 - Issue 1
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Coronaviruses

Healthy outcomes of patients with COVID-19 two years after the infection: a prospective cohort study

Dapeng Lia Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
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Xuejiao Liaoa Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
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Zhi Liua Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
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Zhenghua Maa Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
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Jingke Donga Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
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Guoqin Zhenga Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
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Mei Zia Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-0488-8433View further author information
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Fang Wanga Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaView further author information
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Qing Hea Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaCorrespondence[email protected]
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Guobao Lia Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaCorrespondence[email protected]
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Zheng Zhanga Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of China;b Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science, Shenzhen, People’s Republic of China;c Guangdong Key Laboratory for Anti-infection Drug Quality Evaluation, Shenzhen, People’s Republic of ChinaCorrespondence[email protected]
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Lei Liua Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of China;b Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science, Shenzhen, People’s Republic of ChinaCorrespondence[email protected]
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Pages 2680-2688 | Received 02 Aug 2022, Accepted 04 Oct 2022, Published online: 04 Nov 2022

Figures & data

Table 1. Baseline characteristics.

Figure 1. Ten most common symptoms of long COVID at two years.

Figure 1. Ten most common symptoms of long COVID at two years.

Table 2. Healthy outcomes in patients at 2 years after the infection.

Figure 2. Changes in (A) CT abnormality and (B) CT severity scores over time. The kinetics of CT severity scores at consecutive time points were investigated using Friedman's test (grouping by individual). The Kendall’s W was used as the measure of the Friedman test effect size. The paired Wilcoxon test was used for comparing differences between two consecutive time points. Plots show individual score trajectories as thin grey lines, red lines represent means, and coloured areas represent mean ± standard deviation. The figure shows the number of individuals who completed a series of consecutive CT scans in 74 cases.

Figure 2. Changes in (A) CT abnormality and (B) CT severity scores over time. The kinetics of CT severity scores at consecutive time points were investigated using Friedman's test (grouping by individual). The Kendall’s W was used as the measure of the Friedman test effect size. The paired Wilcoxon test was used for comparing differences between two consecutive time points. Plots show individual score trajectories as thin grey lines, red lines represent means, and coloured areas represent mean ± standard deviation. The figure shows the number of individuals who completed a series of consecutive CT scans in 74 cases.

Table 3. The distribution of parameters in kidney and liver function at two years after infection

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