Early neurosyphilis with serofast state

Figures & data

Table 1. Serologic test results and CSF analysis in early neurosyphilis patient with seraofast status.

		Last 2 years*	At admission	One-year follow-up
CSF analysis	WBC count (normal range <5)		16	2
	Protein concentration (normal range < 0.45 g/L)		0.85	0.74
	Glucose concentration (normal range: 2.22–3.89 mmol/L)		5	3.7
	qPCR tpp47/ploA**		Negative	Negative
	VDRL**		Positive	Negative
	CSF albumin (mg/L) (normal range <350 g/L)		488	253
	CSF IgG (normal range:10–50 mg/L)		151	106
	CSF/serum albumin quotient (Q.alb) (normal range <0.65%)		–	1.06
	CSF/serum IgG quotient (Q.IgG) (normal range <0.7%)		–	0.83
Serum	Treponemal test***	Negative	Positive (>45)	–
	Nontreponemal test (RPR)****	Negative	16	16

Abbreviations: CSF; cerebrospinal fluid; RT-PCR: real-time polymerase chain reaction; RPR: rapid plasma regain; VDRL: venereal disease research laboratory; and WBC: white blood cell.

*Previous Treponema pallidum serologies were negative in this patient from any time within the last 2 years prior to diagnosis.

**RT-PCR on QuantStudio™ 5 Real-Time PCR System (ThermoFisher). polA and Tpp47 genes were amplified in LCS using PCR assays.

***Using immunoenzymatic assays for the detection of anti-Treponema pallidum antibodies.

****NADAL® VDRL: Agglutination tests providing a qualitative and semi-quantitative determination of plasma regain (antibodies “anti-cardiolipin” (aCL) against some components of damaged tissue from patients infected with Treponema pallidum).

Data availability statement

Data are available on request due to privacy restrictions. The data presented in this case study are available on request from the corresponding author.