Metallocene-containing polyesters from reaction of 3,5-pyridinedicarboxylic acid and metallocene dihalides and their preliminary ability to inhibit cancer cell growth

Abstract

Abstract

Polyesters were rapidly formed employing the interfacial condensation of Group VB and vanadocene dihalides with 3,5-purinedicarboxylic acid. Infrared spectroscopy shows the formation of metal–oxygen bonds. The products have a largely distorted non-bridging geometry about the metal atom. Matrix-assisted laser desorption/ionization mass spectrometry results are consistent with the formation of the polyesters. The polymers exhibit inhibition of the growth of pancreatic, colon, breast, and prostate cancer cell lines.

Keywords:

• Group VA metallocene polymers
• titanocene polymers
• zirconocene polymers
• hafnocene polymers
• vanadocene polymers
• 3,5-pyridinedicarboxylic acid
• interfacial polymerization
• pancreatic cancer
• breast cancer
• colon cancer
• prostate cancer

Disclosure statement

No potential conflict of interest was reported by the authors.