The variability of PNPLA3 gene as a potential marker of cold adaptation in Yakuts

Nadezhda Ivanovna Pavlovaa Laboratory of Heritable Pathology, Federal State Budgetary Scientific Institution “Yakut Science Center of Complex Medical Problems”, Yakutsk, RussiaCorrespondence[email protected]

Alexey Alexeevich Bochurova Laboratory of Heritable Pathology, Federal State Budgetary Scientific Institution “Yakut Science Center of Complex Medical Problems”, Yakutsk, Russia

Vladislav Amirovich Alekseevb The laboratory of Immunological Research, Federal State Budgetary Scientific Institution “Yakut Science Center of Complex Medical Problems”, Yakutsk, Russia

Lyubov Akhmedovna Sydykovac Candidate of Medical Sciences, Head of the Department “Propaedeutic and Faculty Therapy with Endocrinology and Medical Physical Culture”; North-Eastern Federal University, Yakutsk, Russia

Vladimir Vladimirovich Dodokhovd Candidate of Biological Sciences, Senior Lecturer Federal State Budgetary Educational Institution of Higher Education Arctic state agrotechnological University, Yakutsk, Russia

Khariton Alekseevich Kurtanove Candidate of Medical Sciences, Senior Researcher, Department of Ecology and Medical Biochemistry, Biotechnology, Russia;f Institute for Biological Problems of Cryolithozone of Siberian Branch of Russian Academy of Science, Yakutsk, Russia

Alexey Vasilievich Krylova Laboratory of Heritable Pathology, Federal State Budgetary Scientific Institution “Yakut Science Center of Complex Medical Problems”, Yakutsk, Russia

show all

Figures & data

Table 1. Frequency of allele variants and missense mutations of the PNPLA3 gene in the Yakut population and in the populations of the 1000 Genomes project.

Download CSV Display Table

Table 2. Possible haplotypes at two loci of the PNPLA3 gene.

Download CSV Display Table

Figure 1. Linkage mismatch in the PNPLA3 gene.

Note. The colour of the cell indicates the strength of the bond between SNPs: red – strong bond (D’= 1, LOD > 2), white – weak bond (D’ < 1, LOD < 2). Abbreviations: YKT – Yakut from the Republic of Sakha (Yakutia), Russia; AFR – African; AMR – American; EAS – East Asian; EUR – European; SAS – South Asian.

Table 3. The distribution of genotypes of PNPLA3 rs738409 and rs2294918 polymorphisms in Yakuts and some other ethnical groups according to the 1000 Genomes project.

Download CSV Display Table

Table 4. Frequency of I148M–E434K haplotypes in the studied group of Yakuts and in the populations from the 1000 Genomes project.

Download CSV Display Table

Table 5. Distribution of diplotypes for two SNP markers of the PNPLA3 gene in the Yakut population and in the populations of the 1000 Genomes project.

Download CSV Display Table

The variability of PNPLA3 gene as a potential marker of cold adaptation in Yakuts

Table 1. Frequency of allele variants and missense mutations of the PNPLA3 gene in the Yakut population and in the populations of the 1000 Genomes project.

Table 2. Possible haplotypes at two loci of the PNPLA3 gene.

Table 3. The distribution of genotypes of PNPLA3 rs738409 and rs2294918 polymorphisms in Yakuts and some other ethnical groups according to the 1000 Genomes project.

Table 4. Frequency of I148M–E434K haplotypes in the studied group of Yakuts and in the populations from the 1000 Genomes project.

Table 5. Distribution of diplotypes for two SNP markers of the PNPLA3 gene in the Yakut population and in the populations of the 1000 Genomes project.

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

The variability of PNPLA3 gene as a potential marker of cold adaptation in Yakuts

Figures & data

Table 1. Frequency of allele variants and missense mutations of the PNPLA3 gene in the Yakut population and in the populations of the 1000 Genomes project.

Table 2. Possible haplotypes at two loci of the PNPLA3 gene.

Table 3. The distribution of genotypes of PNPLA3 rs738409 and rs2294918 polymorphisms in Yakuts and some other ethnical groups according to the 1000 Genomes project.

Table 4. Frequency of I148M–E434K haplotypes in the studied group of Yakuts and in the populations from the 1000 Genomes project.

Table 5. Distribution of diplotypes for two SNP markers of the PNPLA3 gene in the Yakut population and in the populations of the 1000 Genomes project.

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date