Blood pressure lowering, antidyslipidemic and nitric oxide modulatory effects of methanol extract of struchium sparganophora leaves on dexamethasone-salt model of hypertension in rats

Figures & data

Figure 1. Effect of Struchium sparganophora leaf methanol extract on changes in body weights of dexamethasone-induced hypertensive rats

Figure 2. Effect of methanol extract of Struchium sparganophora leaves on (a) systolic and (b) diastolic blood pressure in dexamethasone induced hypertensive rats

Table 1. Effect of Struchium sparganophora leaf methanol extract on lipid profile in dexamethasone-induced hypertensive rats

Groups	Total Cholesterol (mg/dL)	HDL-CHOL (mg/dL)	LDL-CHOL (mg/dL)	TRIG (mg/dL)	VLDL (mg/dL)
Control	40.37 ± 1.20	14.22 ± 3.12	11.42 ± 0.21	153.6 ± 12.09	30.60 ± 2.42
DEX	48.94 ± 3.20	9.09 ± 0.31^a	12.20 ± 0.08	143.8 ± 0.43	28.76 ± 0.086
DEX + NIF	46.87 ± 4.43	10.71 ± 0.31^a	10.79 ± 0.00	153.4 ± 15.01	30.68 ± 3.01
DEX + NIF +SPA 300	48.53 ± 1.88	12.24 ± 0.21^b	19.78 ± 1.37^abc	84.14 ± 1.65^abc	16.83 ± 0.33^abc
DEX + SPA 300	46.31 ± 11.13	12.60 ± 0.21^b	22.92 ± 0.07^abc	108.9 ± 5.42^abc	21.78 ± 1.08^abc
DEX + SPA 600	58.62 ± 4.47^a	12.42 ± 0.00^b	18.72 ± 1.31^abc	103.3 ± 11.15^abc	20.66 ± 2.23^abc

Results were expressed as mean ± standard deviation (n = 4). ^a Significant when compared to control at p < 0.05, ^b Significant when compared to dexamethasone p < 0.05, ^c Significant when compared to standard drug (Nifedipine) p < 0.05.

Table 2. Effect of Struchium sparganophora leaf methanol extract on cholesterol ratio and atherogenic index in dexamethasone-induced hypertensive rats

Groups	Cholesterol ratio	Atherogenic index
Control	2.84	1.84
DEX	5.38	4.39
DEX+NIF	4.38	3.38
DEX+NIF+SPA 300	3.96	2.96
DEX+SPA 300	3.68	2.68
DEX+SPA 600	4.72	3.71

Figure 3. Effect of Struchium sparganophora leaf methanol extract on nitric oxide level in dexamethasone-induced hypertensive rats. ^a Significant when compared to control p < 0.05. ^b Significant when compared to dexamethasone p < 0.05. ^c Significant when compared to standard drug (Nifedipine) p < 0.05