Chemoprotection by Kolaviron of Garcinia kola in Benzene-induced leukemogenesis in Wistar rats

Figures & data

Figure 1. Photomicrograph of peripheral blood smear of representative leukemic rats showing the presence of blast (black arrow) and poikilocytosis (blue arrow).

Table 1. Effect of kolaviron on hematological parameters and blood morphology of benzene-induced leukemia in rats

	PCV %	HGB g/dl	RBC x 10^12/L	PLT × 10^9/L	WBC × 10^9/L	% Blast	ANISD	POIK
CTRL	45.33 ± .52)	15.00 ± 1.00	7.60 ± 0.32	649.67 ± 57.55	9.17 ± 1.96	-	-	-
LKM	41.75 ± 2.22	13.45 ± 0.70	6.98 ± 0.65	807.25 ± 131.00	12.60 ± 2.14	5	++	++
KV	51.33 ± 1.53	16.83 ± 0.25	8.21 ± 0.12	617.00 ± 32.36	6.57 ± 0.85	-	-	-
LKM + KV	44.67 ± 5.51	14.83 ± 1.89	7.21 ± 1.06	705.33 ± 98.01	8.17 ± 1.59	2	+	+

PCV- Pack cell Volume, HGB- Hemoglobin, RBC- Red blood cell, PLT- Platelets, WBC- White blood cell, ANISD- Anisocytosis, POIK- Poikilocytosis

- = absent, + = mildly present and ++ = moderately present

Figure 2. Photomicrograph showing the Influence of kolaviron on bone marrow architecture of benzene-induced leukemia in wistar rats.

Figure 3. Effect of kolaviron on formation of micronucleated polychromatic erythrocytes (mPCEs) in benzene-induced leukemia in wistar rats.

Data are expressed as mean ±S.D for six rats in each group *significantly different from the control p < 0.05^# significantly different from the LKM group

Figure 4. Effect of kolaviron on plasma oxidative stress markers: Advanced Oxidation Protein Products—AOPPs (A), total thiol (B) and plasma activity of arylesterase (C) on benzene-induced leukemia in Wistar rats.

Data are expressed as mean ±S.D for six rats in each group *significantly different from the control p < 0.05^# significantly different from the LKM group