Cerebral perfusion and its association with serum endothelin-1 in multiple sclerosis

Figures & data

Table 1. Comparison between patient group and control group as regards ET-1 serum level by (ng/l).

	Patients group (No. = 30)				Control group (No. = 20)				Independent t-test
	Mean	SD	Min	Max	Mean	SD	Min	Max	t	P-value
ET-1 (ng/l)	128.24	45.79	87	294.5	13.91	3.56	9	23	11.107	<0.001**

** Highly significant.

Table 2. Comparison between patient group and control group as regards MTT, CBV and CBF in NAWM.

	Patients group (No. = 30)				Control group (No. = 20)				Independent t-test
	Mean	SD	Min	Max	Mean	SD	Min	Max	t	P-value
MTT (NAWM)	3.72	1.07	2.1	5.7	1.54	0.35	1.1	2.2	8.832	<0.001**
CBV (NAWM)	2.98	0.56	1.9	4	4.10	0.39	3.6	5.2	−7.811	<0.001**
CBF (NAWM)	24.81	2.56	19	29	33.15	1.80	28	36	−12.613	<0.001**

** Highly significant.

Table 3. Comparison between patient group and control group as regards MTT, CBV and CBF in deep gray matter (DGM).

	Patients group (No. = 30)				Control group (No. = 20)				Independent t-test
	Mean	SD	Min	Max	Mean	SD	Min	Max	t	P-value
MTT (DGM)	3.46	0.99	2	5.3	1.41	0.33	1	2.1	8.954	<0.001**
CBV (DGM)	3.22	0.58	2.1	4.3	4.68	0.49	4.1	5.8	−9.150	<0.001**
CBF (DGM)	26.46	2.71	21	30	34.56	1.60	32	38	−11.968	<0.001**

** Highly significant.

Figure 1. Correlation between serum levels of ET-1 and EDSS.

Table 4. Correlation between ET-1 and EDSS, duration of illness and number of attacks in patients group.

	ET-1
	R	P
EDSS	0.779	<0.001**
Duration of illness	0.616	0.000**
Number of attacks	0.614	0.000**

Table 5. Correlation between EDSS, MTT, CBV and CBF in NAWM in patients group.

	EDSS
	r	P-value
MTT (NAWM)	0.906	<0.001**
CBV (NAWM)	−0.809	<0.001**
CBF (NAWM)	−0.856	<0.001**

Table 6. Correlation between EDSS and MTT, CBV and CBF in DGM of patients group.

	EDSS
	r	P-value
MTT (DGM)	0.841	<0.001**
CBV (DGM)	−0.815	<0.001**
CBF (DGM)	−0.901	<0.001**

Figure 2. Correlation between serum levels of ET-1 and (CBF) in NAWM.

Figure 3. Correlation between serum levels of ET-1 and (CBF) in DGM.

Figure 4. Cerebral blood flow (CBF) and mean transit time (MTT) color-coded maps in MS patient show decreased perfusion with decreased CBF and increased MTT (black arrows).

Figure 5. Cerebral blood flow (CBF) and cerebral blood volume (CBV) color-coded maps in MS patient with white matter lesion show perfusion changes in comparison to contralateral normal-appearing white matter (NAWM).

Table 7. Correlation between ET-1 and MTT, CBV and CBF in NAWM of patients group.

	ET-1
	R	P-value
MTT (NAWM)	0.818	<0.001**
CBV (NAWM)	−0.693	<0.001**
CBF (NAWM)	−0.796	<0.001**

Table 8. Correlation between ET-1 and MTT, CBV and CBF in DGM of patients group.

	ET-1
	R	P-value
MTT (DGM)	0.785	<0.001**
CBV (DGM)	−0.770	<0.001**
CBF (DGM)	−0.793	<0.001**