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Original article

Molecular docking and insecticidal activity of Pyrus communis L. extracts against disease vector, Musca domestica L. (Diptera: muscidae)

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Pages 800-811 | Received 01 Jul 2023, Accepted 09 Nov 2023, Published online: 28 Nov 2023

Figures & data

Figure 1. The bubble chart represents a. larval mortality; b. pupal mortality, and c. adult emergency.

Figure 1. The bubble chart represents a. larval mortality; b. pupal mortality, and c. adult emergency.

Table 1. Lethal concentrations of methanol and n-hexane extracts from leaves of P. communis against M. domestica larvae.

Figure 2. Box-Plot chart representing larval time, pupal time, and total development times for treated groups.

Figure 2. Box-Plot chart representing larval time, pupal time, and total development times for treated groups.

Figure 3. The fitted line chart directly compares the treated groups’ growth index and concentration.

Figure 3. The fitted line chart directly compares the treated groups’ growth index and concentration.

Figure 4. The bar chart represents the number of eggs laid in relation to the calculated LC values (ppm) for all treated groups.

Figure 4. The bar chart represents the number of eggs laid in relation to the calculated LC values (ppm) for all treated groups.

Figure 5. Pie chart representing hatched to non-hatched ratios for all treated groups at LC25, 50, and 75.

Figure 5. Pie chart representing hatched to non-hatched ratios for all treated groups at LC25, 50, and 75.

Table 2. Chi-square of hatched and non-hatched eggs laid by M. domestica females emerged from larvae treated with lethal concentrations of tested extracts.

Figure 6. The line chart represents the score of 53 molecules docked against Ls-AChBP (PDB ID: 2zju).

Figure 6. The line chart represents the score of 53 molecules docked against Ls-AChBP (PDB ID: 2zju).

Figure 7. 2D & 3D interaction of tetratetracontane, octacosyl acetate, hexatriacontane, eicosyl heptafluorobutyrate, bis (2-ethylhexyl) phthalate complexes against the active site of Ls-AChBP (PDB ID: 2zju). Hydrogen bonds are displayed in cyan & H-pi-bonds in dark magenta.

Figure 7. 2D & 3D interaction of tetratetracontane, octacosyl acetate, hexatriacontane, eicosyl heptafluorobutyrate, bis (2-ethylhexyl) phthalate complexes against the active site of Ls-AChBP (PDB ID: 2zju). Hydrogen bonds are displayed in cyan & H-pi-bonds in dark magenta.

Table 3. Docking results inside Ls-AChBP (PDB ID: 2zju) active spots, arranged from the negatively highest to the lowest score.