Figures & data
Figure 1. Model showing the potential role of Lmx1b and miR135a2 in modulating the Wnt pathway and influencing midbrain size, mDA progenitor specification and neurogenesis. The transcription factor Lmx1b, directly or indirectly, drives Wnt1/Wnt signaling and the Rmst/miR135a2 transcriptional unit. miR135a2, on the other hand, represses Lmx1b and Wnt pathway targets, among other factors. Thus, the levels of this transcription factor-microRNA pair influence the net levels of Wnt1/Wnt signaling during midbrain development, impacting overall size, patterning and expansion of the mDA progenitor pool, at least in part via modulation of downstream transcription factors like Lmx1a.
