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Cogent Chemistry Volume 2, 2016 - Issue 1
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Research Article

Quantitative structure activity relationship study of anticonvulsant activity of α_substituted acetamido-N-benzylacetamide derivatives

Usman AbdulfataiDepartment of Chemistry, Ahmadu Bello University, Zaria, NigeriaCorrespondence[email protected]
View further author information
,
Adamu UzairuDepartment of Chemistry, Ahmadu Bello University, Zaria, NigeriaView further author information
&
Sani UbaDepartment of Chemistry, Ahmadu Bello University, Zaria, NigeriaView further author information
|
Juan Ignacio MeloUniversidad de Buenos Aires Facultad de Ciencias Exactas y Naturales, ArgentinaView further author information
(Reviewing Editor)
Article: 1166538 | Received 21 Oct 2015, Accepted 11 Mar 2016, Published online: 22 Apr 2016

Figures & data

Figure 1. General structure of α_substituted acetamido-N-benzylacetamide derivatives.

Figure 1. General structure of α_substituted acetamido-N-benzylacetamide derivatives.

Table 1. Biological activities of training and test set derivatives

Figure 2. Training set plot of model 1.

Figure 2. Training set plot of model 1.

Table 2. Minimum recommended value of validated parameters for generally acceptable QSAR

Table 3. List of some descriptors used in this study

Table 4. Pearson’s correlation matrix for descriptors used in QSAR model for the activities of anticonvulsant molecules

Table 5. Validation of the genetic function approximation from material studio

Table 6. Experimental and predicted values of activity data

Figure 3. Test set plot of model 1.

Figure 3. Test set plot of model 1.

Figure 4. Residual plot of model 1.

Figure 4. Residual plot of model 1.

Table 7a. External validation of Model-1

Table 7b. External validation of Model 1

Table 8. Univariate analysis of the Inhibition data

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