Quercetin, a polyphenolic phytochemical prevents sodium azide-induced extra-hepatic oxidative stress in rats

Figures & data

Table 1. Relative organ weights of quercetin treatments in NaN₃-induced toxicity in rats

Groups	Relative brain weight (%)	Relative lung weight (%)	Relative heart weight (%)
Control	1.38 ± 0.12^b	0.78 ± 0.07^b	0.38 ± 0.02^a
NaN3	0.93 ± 0.03^a	0.59 ± 0.03^a	0.40 ± 0.01^a
NaN3 ± quercetin	1.18 ± 0.08^b	0.92 ± 0.13^b	0.38 ± 0.03^a
Quercetin	1.23 ± 0.08^b	0.72 ± 0.05^ab	0.42 ± 0.05^a

Values are expressed as mean ± standard error of mean (n = 5). Values labeled with different superscript are statistically significant (p < 0.05). Relative organ (brain, lung, heart) weight = (organ weight/final body weight) × 100.

Table 2. Protection of quercetin on some plasma biochemical parameters in NaN₃-induced toxicity

Groups	CHOL (mg/dl)	TG (mg/dl)	HDL-CHOL (mg/dl)
Control	55.30 ± 4.16^b,c	72.54 ± 10.30^a,b	47.48 ± 5.92^a
NaN3	41.69 ± 2.69^a	60.95 ± 7.57a	50.94 ± 1.15^a
NaN3 ± quercetin	45.25 ± 3.36^a,b	89.37 ± 6.49b	37.17 ± 6.36^a
Quercetin	60.16 ± 3.76^c	72.20 ± 4.96ab	47.84 ± 0.36^a

Values are expressed as mean ± standard error of mean (n = 5). Values labeled with different superscript are statistically significant (p < 0.05).

Table 3. Nephroprotection of quercetin in NaN₃-induced renal toxicity in plasma of rats

Groups	TP (g/dl)	Urea (mg/dl)	Uric acid (mg/dl)	Creatinine (mg/dl)
Control	6.31 ± 0.24^a	56.68 ± 0.33^a	4.63 ± 0.09^a	0.74 ± 0.04^a
NaN3	7.73 ± 0.20^b	269.19 ± 4.06^b	20.51 ± 0.19^b	1.73 ± 0.09^b
NaN3 ± quercetin	6.52 ± 0.22^a	55.26 ± 1.11^a	4.30 ± 0.09^a	0.82 ± 0.07^a
Quercetin	7.02 ± 0.23^a	55.54 ± 0.99^a	4.40 ± 0.12^a	0.79 ± 0.05^a

Notes: Values are expressed as mean ± standard error of mean (n = 5). Values labeled with different superscript are statistically significant (p < 0.05).

Figure 1. Effects of quercetin in NaN₃-induced brain, lung, and heart lipid peroxidation in rats.

Bars are mean values of MDA ± SEM; n = 5. Bars with different letters are significantly different (p < 0.05). SAZ = sodium azide; QUER = quercetin.

Figure 2. Effects of quercetin on brain, lung, and heart GSH levels in NaN₃-treated rats.

Bars are mean levels of GSH ± SEM; n = 5. Bars with different letters are significantly different (p < 0.05). SAZ = sodium azide; QUER = quercetin.

Figure 3. Effects of quercetin on brain, lung, and heart GPx activities in NaN₃-treated rats.

Bars are mean activities of GPx ± SEM; n = 5. Bars with different letters are significantly different (p < 0.05). SAZ = sodium azide; QUER = quercetin.

Figure 4. Effects of quercetin on brain, lung, and heart CAT activities in NaN₃-treated rats.

Bars are mean activities of CAT ± SEM; n = 5. Bars with different letters are significantly different (p < 0.05). SAZ = sodium azide; QUER = quercetin.

Figure 5. Effects of quercetin on brain, lung, and heart SOD activities in NaN₃-treated rats.

Bars are mean activities of SOD ± SEM; n = 5. Bars with different letters are significantly different (p < 0.05). SAZ = sodium azide; QUER = quercetin.

Figure 6. Effects of quercetin on brain, lung, and heart GST activities in NaN₃-treated rats.

Bars are mean activities of GST ± SEM; n = 5. Bars with different letters are significantly different (p < 0.05). SAZ = sodium azide; QUER = quercetin.