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Research Article

Evaluating the toxicological effects of agrochemicals on glucocorticoid receptor and serum cortisol level in Mozambique tilapia

, , & ORCID Icon | (Reviewing editor)
Article: 1480338 | Received 08 Apr 2018, Accepted 18 May 2018, Published online: 09 Jun 2018

Figures & data

Figure 1. Serum cortisol level in female and male O. mossambicus.

Note: Significance is reported at *p < 0.05.

Figure 1. Serum cortisol level in female and male O. mossambicus.Note: Significance is reported at *p < 0.05.

Figure 2. 2% agarose gene expression images of GR—glucocorticoid receptor in kidney, thyroid, ovary gills, brain and liver. C—control, CZ—curzate, IMI—imidacloprid, MN—micronutrient mixture, PE—pyzosulphuron ethyl.

Figure 2. 2% agarose gene expression images of GR—glucocorticoid receptor in kidney, thyroid, ovary gills, brain and liver. C—control, CZ—curzate, IMI—imidacloprid, MN—micronutrient mixture, PE—pyzosulphuron ethyl.

Figure 3. Graph showing relative expression pattern of the glucocorticoid receptor (GR) in four different groups of O. mossambicus exposed to agrochemicals.

Note: (*) Denotes the significance of *p < 0.05.

Figure 3. Graph showing relative expression pattern of the glucocorticoid receptor (GR) in four different groups of O. mossambicus exposed to agrochemicals.Note: (*) Denotes the significance of *p < 0.05.

Figure 4. Illustrates the interaction of various genes with glucocorticoid receptor (NR3C1) using pathway commons and Cytoscape software.

Figure 4. Illustrates the interaction of various genes with glucocorticoid receptor (NR3C1) using pathway commons and Cytoscape software.

Figure 5. Conclusion—schematic representation of hypothalamus–pituitary interrenal axis (HPI) under the exposure of agrochemicals (PE—pyzosulphuroethyl, IMI—imidacloprid, MN—micronutrient mixture and CZ—curzate). CRH—cortocotropin releasing hormone, ACTH—adrenocorticotropic hormone, GR—glucocorticoid receptor, C—cortical region, M—medullary region.

Figure 5. Conclusion—schematic representation of hypothalamus–pituitary interrenal axis (HPI) under the exposure of agrochemicals (PE—pyzosulphuroethyl, IMI—imidacloprid, MN—micronutrient mixture and CZ—curzate). CRH—cortocotropin releasing hormone, ACTH—adrenocorticotropic hormone, GR—glucocorticoid receptor, C—cortical region, M—medullary region.