Splenic marginal zone B-cell lymphoma associated with ruptured breast implants: case report and review of the literature

Figures & data

Table 1. Cases of B-cell lymphomas associated with breast implants.

Study	Age (years)	Implant	Time from implantation to lymphoma (years)	Presentation	Treatment	Lymphoma Diagnosis
Cook et al. 1995	56	Silicone Polyurethane	6	Palpable mass and contracture	Mass resection, contracture correction, implant replacement	Follicular lymphoma
Nichter et al. 2012	58	Saline and silicone No additional information available	22	Contracture and axillary lymphadenopathy	Implant removal and capsulectomy	Follicular lymphoma and nodal marginal zone lymphoma
Jones et al. 2014	69	Silicone Smooth, moderate plus	6	Pain and swelling around sternum	Radiation therapy	Primary cutaneous follicle center lymphoma
Smith et al. 2014	83	Silicone Smooth Arion	44	Swelling and fluid surrounding right breast	Implant removal and complete capsulectomy	Diffuse large B-cell lymphoma, not otherwise specified
Moling et al. 2016	48	Silicone Polytech 44-G	4	Fever, splenomegaly, and hemophagocytic lymphohistiocytosis	Implant removal, partial capsulectomy, R-CHOP^a, intrathecal methotrexate	Intravascular large B-cell lymphoma
Chen et al. 2018	34	Silicone Poly-implant prosthesis	14	Recurrent capsular contracture	Implant removal, mastectomy, complete capsulectomy, rituximab	Low-grade B-cell lymphoma/extranodal marginal zone lymphoma
Har-Shai et al. 2019	59	Silicone Textured NAGOR	11	Swelling and fluid surrounding left breast	Implant removal and complete capsulectomy	Anaplastic large cell lymphoma and extranodal marginal zone lymphoma
Geethakumari et al. 2019	74	Saline No additional information available	40	Pain, swelling, and fluid surrounding left breast	Implant removal, complete capsulectomy, V-EPOCH^b + bortezomib, consolidative radiation	Plasmablastic lymphoma
Larrimore et al. 2019	70	Silicone Nontextured	28	Asymptomatic breast mass on imaging	Implant removal and complete capsulectomy	Diffuse large B-cell lymphoma, not otherwise specified
Evans et al. 2020	69	Silicone Textured McGhan	11	Swelling and fluid surrounding right breast	Implant removal, complete capsulectomy, bendamustine + rituximab	Anaplastic large cell lymphoma and extranodal marginal zone lymphoma
Evans et al. 2020	62	Silicone Textured McGhan	36	Swelling and fluid surrounding right breast	Implant removal and complete capsulectomy	Extranodal marginal zone lymphoma
Evans et al. 2020	61	Saline No additional information available	21	Swelling and painful mass	R-CHOP^a	Diffuse large B-cell lymphoma

Figure 1. The patient’s abdominal CT scan demonstrates massive splenomegaly with adjacent abdominal lymphadenopathy.

Figure 2. Microscopic examination of the patient’s peripheral blood smeared reveals atypical lymphocytes with villous morphology (A, 1000x magnification). Her bone marrow contained prominent lymphoid aggregates accounting for approximately 20% of the marrow’s cellularity (B, 200x magnification) that were composed of B-cells positive for CD20 by immunohistochemistry (C, 200x magnification).