The ins and outs of prostaglandin E2 in fever

Figures & data

Figure 1. Transport pathways that might be involved when PGE₂ signals fever in the brain. The green arrows show translocation of systemic PGE₂ across the brain capillary endothelium, or the sided release of endothelium-derived PGE₂, into the brain parenchyma. The red arrows show termination of PGE₂ signaling via removal of PGE₂. Numbers on arrows are discussed in the text.