Figures & data
Figure 1. UCP1 is a key factor on central actions of T3. Central T3 inhibits AMP-activated protein kinase (AMPK) in the ventromedial nucleus of the hypothalamus; this modulates brown adipose tissue thermogenesis and browning of white adipose tissue. Moreover, T3 increases food intake through an elevation of the agouti-related peptide (AgRP) and neuropeptide Y (NPY) expression in the arcuate nucleus. All this actions are dependent of UCP1 expression in brown fat and therefore absent in Ucp1 null mice. 3V: third ventricle.
