Figure 1. Simplified schematic of the mechanisms in endotoxin fever, highlighting the interaction between SP signaling and the cytokine-COX-2-PGE2 axis based on the study in focus [Citation1] (see text for explanation). AA: arachidonic acid; COX-2: cyclooxygenase-2; EP3: prostaglandin EP3 receptor; LPS: lipopolysaccharide; MnPO: median preoptic nuclues; mPGES-1: microsomal PGE2 synthase-1; NK1: neurokinin-1; PGE2: prostaglandin E2; POA: preoptic area; TLR4: Toll-like receptor 4.
![Figure 1. Simplified schematic of the mechanisms in endotoxin fever, highlighting the interaction between SP signaling and the cytokine-COX-2-PGE2 axis based on the study in focus [Citation1] (see text for explanation). AA: arachidonic acid; COX-2: cyclooxygenase-2; EP3: prostaglandin EP3 receptor; LPS: lipopolysaccharide; MnPO: median preoptic nuclues; mPGES-1: microsomal PGE2 synthase-1; NK1: neurokinin-1; PGE2: prostaglandin E2; POA: preoptic area; TLR4: Toll-like receptor 4.](/cms/asset/bd12b9ce-258f-49bb-bcde-145ab4b91392/ktmp_a_1567247_f0001_b.gif)
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