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Commentary

miR-15/miR-16 loss, miR-21 upregulation, or deregulation of their target genes predicts poor prognosis in prostate cancer patients

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Article: e1109744 | Received 03 Aug 2015, Accepted 12 Oct 2015, Published online: 10 Jun 2016

Figures & data

Figure 1. Molecular mechanisms whereby alterations in miR-15, miR-16, and miR-21 result in aberrant TGF-β signaling. Hematoxylin and Eosin staining of patient tissues is reported. BCL-2, B-cell lymphoma; CXCR-4, C-X-C chemokine receptor type 4; CYC D1, cyclin D1; IHH, Indian hedgehog; IL-11, Interleukin 11; RUNX-2, Runt-related transcription factor 2; RANKL, Receptor activator of nuclear factor kappa-B ligand; TGF-β, Transforming growth factor β; WNT-3A, Wingless-Type MMTV Integration Site Family, Member 3A.

Figure 1. Molecular mechanisms whereby alterations in miR-15, miR-16, and miR-21 result in aberrant TGF-β signaling. Hematoxylin and Eosin staining of patient tissues is reported. BCL-2, B-cell lymphoma; CXCR-4, C-X-C chemokine receptor type 4; CYC D1, cyclin D1; IHH, Indian hedgehog; IL-11, Interleukin 11; RUNX-2, Runt-related transcription factor 2; RANKL, Receptor activator of nuclear factor kappa-B ligand; TGF-β, Transforming growth factor β; WNT-3A, Wingless-Type MMTV Integration Site Family, Member 3A.

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