Antitumor activity of LSD1 inhibitors in lung cancer

Figures & data

Figure 1. Putative mechanism of action of LSD1 inhibitors. GSK2879552 inhibits the demethylation of histones by LSD1, leading to changes in the expression of neuroendocrine marker genes. Alterations in gene expression may give rise to in vitro and in vivo growth inhibition of small cell lung cancer cells.⁵

Mohammad HP, Smitheman KN, Kamat CD, Soong D, Federowicz KE, Van Aller GS, Schneck JL, Carson JD, Liu Y, Butticello M, et al. A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell 2015 Jul; 28(1):57-69; PMID:26175415; http://dx.doi.org/10.1016/j.ccell.2015.06.002

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