Figures & data
Figure 1. Possible role for selective JAK2 inhibition in JAK2-amplified TNBC. Growth factors (GF), hormones (H), and interleukin cytokines (IL) activate a diversity of JAK family-bound receptors. JAK occupancy on these receptors can dictate the nature of downstream STAT responders. Specific STATs may have pro-tumor or pro-host effects within the tumor. Our data suggest that in JAK2-amplified TNBC, specific JAK2 inhibition may selectively target JAK2-mediated pro-tumor signals without compromising pro-host JAK1/3/TYK signals.
