Figures & data
Figure 1. Single-cell developmental classification and DDPR prediction to model relapse in BCP-ALL.
At diagnosis, expanded leukemic cells have the closest phenotypic similarity to cells across the pre-pro-B to pre-BI transitional populations of normal B-cell development. BCP-ALL cells with distinct cellular features and the highest phenotypic similarity to pro-BII and pre-BI cells exist at diagnosis in patients who will go on to relapse. Specifically, pro-BII-like cells with high basal activation of either prpS6 or 4EBP1, and pre-BI-like cells with high basal activation of SYK and lack of CREB and rpS6 response to pre-B cell receptor engagement. These cells exist at diagnosis but persist despite the pressure of treatment to mediate eventual relapse.
