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Molecular & Cellular Oncology Volume 5, 2018 - Issue 5
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DNA repair synthesis and histone deposition partner during homologous recombination

Amira ElbakryRadiation Biology and DNA Repair, Darmstadt University of Technology, Darmstadt, GermanyView further author information
,
Szilvia JuhászRadiation Biology and DNA Repair, Darmstadt University of Technology, Darmstadt, GermanyORCID Iconhttp://orcid.org/0000-0001-7991-5438View further author information
ORCID Icon,
Arthur MathesRadiation Biology and DNA Repair, Darmstadt University of Technology, Darmstadt, GermanyORCID Iconhttp://orcid.org/0000-0001-8761-7297View further author information
ORCID Icon &
Markus LöbrichRadiation Biology and DNA Repair, Darmstadt University of Technology, Darmstadt, GermanyCorrespondence[email protected]
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Article: e1511210 | Received 27 Jul 2018, Accepted 09 Aug 2018, Published online: 05 Sep 2018

Figures & data

Figure 1. Histone dynamics in replication, repair synthesis and transcription. Chromatin remodeling is a common requirement for the regulation of DNA and RNA synthesis. Distinct chromatin remodelers and chaperons direct the deposition of histone variants during replication (chromatin assembly factor-1, CAF-1), repair synthesis in homologous recombination (alpha-thalassemia mental retardation X-linked protein, ATRX, and the chaperon death domain associated protein, DAXX) and transcription (histone regulator A, HIRA). PCNA: proliferating nuclear cell antigen; RNA Pol: RNA polymerase II.

Figure 1. Histone dynamics in replication, repair synthesis and transcription. Chromatin remodeling is a common requirement for the regulation of DNA and RNA synthesis. Distinct chromatin remodelers and chaperons direct the deposition of histone variants during replication (chromatin assembly factor-1, CAF-1), repair synthesis in homologous recombination (alpha-thalassemia mental retardation X-linked protein, ATRX, and the chaperon death domain associated protein, DAXX) and transcription (histone regulator A, HIRA). PCNA: proliferating nuclear cell antigen; RNA Pol: RNA polymerase II.

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