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Molecular & Cellular Oncology Volume 6, 2019 - Issue 3
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Tracking tumor evolution one-cell-at-a-time

Ankur SharmaCancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, SingaporeCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-6862-136XView further author information
ORCID Icon &
Ramanuj DasGuptaCancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, SingaporeCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-9015-3729View further author information
ORCID Icon
Article: 1590089 | Received 11 Feb 2019, Accepted 01 Mar 2019, Published online: 02 Apr 2019

Figures & data

Figure 1. Divergent modes of tumor evolution. (a) Drug-induced stem-cell switch mediated epigenetic plasticity in phenotypically homogenous tumors. (b) Darwinian selection of pre-existing drug-resistance cells in phenotypically heterogeneous tumors. (VIM-Vimentin promoter).

Figure 1. Divergent modes of tumor evolution. (a) Drug-induced stem-cell switch mediated epigenetic plasticity in phenotypically homogenous tumors. (b) Darwinian selection of pre-existing drug-resistance cells in phenotypically heterogeneous tumors. (VIM-Vimentin promoter).

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