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Molecular & Cellular Oncology Volume 6, 2019 - Issue 3
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USP30: protector of peroxisomes and mitochondria

Victoria RiccioBiochemistry Department, University of Toronto, Toronto, Canada;Cell Biology Department, Hospital for Sick Children, Toronto, CanadaCorrespondence[email protected] [email protected]
,
G. Angus McQuibbanBiochemistry Department, University of Toronto, Toronto, Canada
&
Peter Kijun KimBiochemistry Department, University of Toronto, Toronto, Canada;Cell Biology Department, Hospital for Sick Children, Toronto, CanadaORCID Iconhttp://orcid.org/0000-0001-6626-0575
ORCID Icon
Article: 1600350 | Received 12 Mar 2019, Accepted 25 Mar 2019, Published online: 16 Apr 2019

Figures & data

Figure 1. USP30 regulates basal pexophagy.

a) Under basal conditions, USP30 and PEX2 work in opposition to maintain peroxisome homeostasis. b) During pexophagy induction, USP30 can no longer maintain low peroxisome ubiquitination, autophagy receptors NBR1 and sequestosome 1 (p62) are recruited to facilitate engulfment by the autophagosome and peroxisomes are lost.

Figure 1. USP30 regulates basal pexophagy.a) Under basal conditions, USP30 and PEX2 work in opposition to maintain peroxisome homeostasis. b) During pexophagy induction, USP30 can no longer maintain low peroxisome ubiquitination, autophagy receptors NBR1 and sequestosome 1 (p62) are recruited to facilitate engulfment by the autophagosome and peroxisomes are lost.

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