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Back Matter

Translation control can shape TP53-dependent cell fate

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Article: 1767483 | Received 21 Apr 2020, Accepted 06 May 2020, Published online: 23 Jun 2020

Figures & data

Figure 1. The RBP repertoire modulates p53-dependent cell fate. The p53 sequence-specific transcription factor controls a vast network of direct targets genes by binding to variations of Response Element (RE) binding sites. This multifunctional p53-transcriptional network can be modulated at the translational level, for example by PCBP2 and DHX30 targeting the CGPD-motif depending on their relative levels of expression, to influence cell fate.

Figure 1. The RBP repertoire modulates p53-dependent cell fate. The p53 sequence-specific transcription factor controls a vast network of direct targets genes by binding to variations of Response Element (RE) binding sites. This multifunctional p53-transcriptional network can be modulated at the translational level, for example by PCBP2 and DHX30 targeting the CGPD-motif depending on their relative levels of expression, to influence cell fate.

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