https://orcid.org/0000-0003-2770-5847
Figures & data
Figure 1. Relationship between aging, autophagy, and TP53. a. Autophagy inhibition causes enhanced transactivation of tumor suppressor protein p53 (TP53) target genes, resulting in accelerated aging of mice. b. TP53 inactivation results in enhanced autophagy (due to the absence of cytoplasmic TP53), increasing longevity in nematodes. c. Hypothetical experimental design to distinguish the roles of cytoplasmic and nuclear TP53 in the aging process. It would be necessary to generate TP53 mutants that are selectively active in the cytoplasm or in the nucleus, to generate genetically modified mice expressing such mutants and to characterize them for age-associated traits.
