The phospho-barcode of RIPK1: complementarity or redundancy?

Figures & data

Figure 1. RIPK1 phosphorylation sites. Receptor-interacting serine/threonine kinase 1 (RIPK1) consists of an N-terminal kinase domain, an intermediate domain harboring a RIP homotypic interaction motif (RHIM) and a C-terminal death domain (DD). The scheme depicts the phosphorylations mediated by RIPK1 (autophosphorylation), component of inhibitor of nuclear factor kappa B kinase complex (CHUK, also known as the inhibitor of κB [IκB] kinase α, IKKα) and inhibitor of nuclear factor kappa B kinase subunit beta (IKBKB, also known as IKKβ), MAPK activated protein kinase 2 (MAPKAPK2, also known as MK2), inhibitor of nuclear factor kappa B kinase subunit epsilon (IKBKE, also known as IKKε), TANK binding kinase 1 (TBK1), and unc-51-like autophagy activating kinase 1 (ULK1). Ser357 (highlighted in red) represents a major ULK1-dependent phospho-acceptor site. The numbering refers to amino acid positions in human RIPK1 (UniProt ID Q13546).