Oncogenic pathway driven by p85β: upstream signals to activate p110

Figures & data

Figure 1. Molecular mechanisms of AXL regulation. Several transcription factors that regulate AXL promoter have been identified. AXL mRNA can also be regulated by tumor suppressive miRNA such as miR-34a and miR-199a/b. At post-translation level, AXL protein is regulated through proteolytic shedding of the extracellular domain or through protein degradation mediated by E3 ligases. In our recent study, p85β inhibits autophagic degradation of AXL by modulating the phosphorylation of E3 ligase TRIM2 and autophagic receptor optineurin.