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Molecular & Cellular Oncology Volume 7, 2020 - Issue 5
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Research Article

Expression patterns and clinical significance of the potential cancer stem cell markers OCT4 and NANOG in colorectal cancer patients

Raheleh Roudia Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran;b Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA
,
Mahboubeh Barodabia Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran;c Department of Pathology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
,
Zahra Madjda Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran;c Department of Pathology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran;d Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
,
Giandomenico Rovielloe Department of Health Sciences, University of Florence, Florence, Italy
,
Silvia Paola Coronaf Department of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Hospital, TriesteORCID Iconhttps://orcid.org/0000-0003-4971-1076
ORCID Icon &
Mahshid Panahia Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran;c Department of Pathology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran;g Department of Pathology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IranCorrespondence[email protected] [email protected]
Article: 1788366 | Received 29 Apr 2020, Accepted 23 Jun 2020, Published online: 14 Jul 2020

Figures & data

Table 1. Correlations between OCT4 and NANOG expressions with clinicopathological parameters in colorectal Cancer

Figure 1. Graphical distribution of included colorectal cancer population based on their ages using histogram plot

Figure 1. Graphical distribution of included colorectal cancer population based on their ages using histogram plot

Figure 2. Expressions of OCT4 and NANOG in colorectal cancer tissues. In each type of marker, the intensity of staining was shown as strong (+3), moderate (+2), and weak (+1) staining (from left to right)

Figure 2. Expressions of OCT4 and NANOG in colorectal cancer tissues. In each type of marker, the intensity of staining was shown as strong (+3), moderate (+2), and weak (+1) staining (from left to right)

Figure 3. The association between expression levels of OCT4 and NANOG. (a) the scatter dot plot is showing the correlation of OCT4 and NANOG markers, (b) the bar chart is showing the percentages of each phenotype

Figure 3. The association between expression levels of OCT4 and NANOG. (a) the scatter dot plot is showing the correlation of OCT4 and NANOG markers, (b) the bar chart is showing the percentages of each phenotype

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