Design and Comprehensive Study of Biodegradable Zinc–based Implants for Bio–medical Applications

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ABSTRACT

Biodegradable implant researches are enhancing nowadays, enduring challenges in programmed degradability and cytocompatibility with connecting tissues. These materials used to implanted, proliferate cellular interaction, degrade and replaced by regenerated natural bone in the living bodies. Distinctive metallic, ceramic and polymer materials were considered and found compatible, enhancing osteoblast and cellular response. Apart from magnesium, zinc and iron metals, alloys and composites are consistent due to their high load-bearing capability, controlled degradation and promising designed biomechanical properties. The properties of various degradable and non-degradable materials are studied here and compared with developed samples’ biomechanical properties. The samples are prepared and fabricated using casting techniques and examined using tensile, compression, hardness and cellular tests. The results are found similar, thus concluded with comparable in-vivo results of previous researchers. Mg.Li and (Zn.Mg).Mn composition is found cytocompatible with programmable biomechanical properties, able to replace Ti-based alloys.

KEYWORDS:

• Cytocompatibility
• zinc alloy
• mechanical properties
• MC3T3.E1 and endothelial cell
• sample characterisation

Conflicts of interest

No potential conflict of interest was reported by the author(s).