High-risk human papillomavirus types in HIV-infected and HIV-uninfected young women in KwaZulu-Natal, South Africa: implications for vaccination

Figures & data

Table 1. Demographic characteristics, HPV and HIV status of the participants in two areas of the KZN province.

	Overall (n = 1223)	Area A (n = 658)	Area B (n = 565)	p value
Age, mean years (SD)	18.91 (2.01)	18.9 (1.90)	18.88 (2.10)	.62 ^a
Age debut, mean age (SD)	16.45 (1.46)	16.4 (1.50)	16.49 (1.41)	.27 ^a
Lifetime sex partners, mean (SD)	1.9 (1.12)	2.0 (1.31)	1.80 (1.04)	.04 ^a
HIV infected n (%)	267 (22)	177 (27)	90 (16)	<.01 ^b
HPV infected n (%)	301 (25)	177 (27)	124 (22)	.05 ^b

^a Independent samples t-test was used to calculate p values.

^b Pearson Chi square test analysis was used to calculate p values.

Table 2. Risk factors associated with HPV infection among young women.

Risk factor	HPV infected n (%)	HPV uninfected n(%)	Bivariate OR (95% CI) ^b	p value	Adjusted OR	p value
Father present ^a	51/297 (17)	212/919 (23)	0.69 (0.49–0.97) ^d	.03	0.62 (0.42–0.93)	.02
Mean age in years (SD)	18.7 (2.01)	18.9 (2.01)	0.95 (0.87–1.01) ^c	.11	0.93 (0.86–1.02)	.12
HIV infection	86/301 (29)	181/922 (20)	1.64 (1.22–2.21) ^d	<.001	1.57 (1.09–2.26)	.01
Condom use ^a	103/226 (46)	324/801 (40)	1.23 (0.92–1.6) ^d	.17	1.19 (0.88–1.61)	.26
Male condom use last week ^a	101/297 (34)	250/918 (27)	0.74 (0.56–0.98)^d	.03	1.13 (0.79–1.61)	.51
Drug use ^a	8/297 (2.70)	40/920 (4.30)	0.61 (0.28–1.32) ^d	.21	–	–
Mean age at sexual debut (SD)	16.4 (1.30)	16.5 (1.50)	0.95 (0.87–1.04) ^c	.25	–	–
Mean no. of children in the household (SD)	2.47 (1.74)	2.59 (1.87)	0.97 (0.90–1.04) ^c	.33	–	–
Mean no. of Lifetime partners (SD)	1.97 (1.24)	1.92 (1.20)	1.03 (0.928–1.15) ^c	.56	–	–
Mother present ^a	180/297 (60)	545/920 (59)	1.06 (0.81–1.38) ^d	.64	–	–
Mean age of menstruation (SD)	13.8 (1.47)	13.9 (1.49)	0.98 (0.90–1.07) ^c	.67	–	–

^a includes only the participants that answered ‘yes’ for that specific variable.

SD: standard deviation.

^b OR: odds ratio; CI: confidence interval.

^c Independent samples t-test was used to calculate p values.

^d Pearson Chi square test analysis was used to calculate p values.

Table 3. The most predominant HPV types among young women.

HPV type	HIV infected	HIV uninfected	Total (n)
	n (%)	n (%)
HPV 16 ^a	25 (9.4)	74 (7.7)	99
HPV 51	13 (4.9)	45 (4.9)	58
HPV 18 ^a	21 (7.9)	35 (3.7)	56
HPV 35	15 (5.6)	35 (3.7)	50
HPV 33 ^a	14 (5.2)	33 (3.5)	47
HPV 56	14 (5.9)	28 (2.9)	42
HPV 45 ^a	10 (3.7)	24 (2.5)	34
HPV 52 ^a	7 (2.6)	25 (2.6)	32
HPV 59	8 (3.0)	23 (2.4)	31
HPV 31 ^a	9 (3.4)	19 (2.0)	28
HPV 58 ^a	6 (2.2)	19 (2.0)	25

^a hr-HPV types covered by the nine-valent vaccine.

Figure 1. Hr-HPV and probable Hr-HPV types prevalence among HIV-infected and HIV-uninfected young women. Dark bars represent hr-HPV types identified among HIV-positive young women and light bars represent those found in HIV-uninfected women.