The influence of a change in septic shock definitions on intensive care epidemiology and outcome: comparison of sepsis-2 and sepsis-3 definitions

Rob G. H. DriessenDepartment of Intensive Care Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands; ;Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands; Correspondence[email protected]

Marcel C. G. van de PollDepartment of Intensive Care Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands; ;Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands; ;School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Centre, Maastricht, The Netherlands

Marianne F. MolDepartment of Intensive Care Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands;

Walther N. K. A. van MookDepartment of Intensive Care Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands;

Ronny M. SchnabelDepartment of Intensive Care Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands;

Figures & data

Table 1. Characteristics of the study population.

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Figure 1. Venn diagram showing overlap of populations.

Table 2. Number of patients meeting the definitions for septic shock according to the Sepsis-2 and Sepsis-3 definitions and the implications for APACHE II score and ICU mortality.

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Table 3. Association between sepsis and mortality in patients with active malignancy.

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Table 4. Association between blood lactate level and ICU mortality in patients with septic shock defined by Sepsis-2 definition after logistic regression (age, sex and co-morbidity).

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Table 5. Association between blood lactate level and in-hospital mortality in patients with septic shock defined by Sepsis-2 definition after logistic regression (age, sexand co-morbidity).

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Table 6. Association between blood lactate level and ICU mortality in patients with septic shock defined by Sepsis-2 definition and no active malignancy after logistic regression (age, sexand co-morbidity) and no active malignancy.

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The influence of a change in septic shock definitions on intensive care epidemiology and outcome: comparison of sepsis-2 and sepsis-3 definitions

Table 1. Characteristics of the study population.

Table 2. Number of patients meeting the definitions for septic shock according to the Sepsis-2 and Sepsis-3 definitions and the implications for APACHE II score and ICU mortality.

Table 3. Association between sepsis and mortality in patients with active malignancy.

Table 4. Association between blood lactate level and ICU mortality in patients with septic shock defined by Sepsis-2 definition after logistic regression (age, sex and co-morbidity).

Table 5. Association between blood lactate level and in-hospital mortality in patients with septic shock defined by Sepsis-2 definition after logistic regression (age, sexand co-morbidity).

Table 6. Association between blood lactate level and ICU mortality in patients with septic shock defined by Sepsis-2 definition and no active malignancy after logistic regression (age, sexand co-morbidity) and no active malignancy.

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The influence of a change in septic shock definitions on intensive care epidemiology and outcome: comparison of sepsis-2 and sepsis-3 definitions

Figures & data

Table 1. Characteristics of the study population.

Table 2. Number of patients meeting the definitions for septic shock according to the Sepsis-2 and Sepsis-3 definitions and the implications for APACHE II score and ICU mortality.

Table 3. Association between sepsis and mortality in patients with active malignancy.

Table 4. Association between blood lactate level and ICU mortality in patients with septic shock defined by Sepsis-2 definition after logistic regression (age, sex and co-morbidity).

Table 5. Association between blood lactate level and in-hospital mortality in patients with septic shock defined by Sepsis-2 definition after logistic regression (age, sexand co-morbidity).

Table 6. Association between blood lactate level and ICU mortality in patients with septic shock defined by Sepsis-2 definition and no active malignancy after logistic regression (age, sexand co-morbidity) and no active malignancy.

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