Predictors of one-year all-cause mortality and infection-related mortality in patients with Staphylococcus aureus bacteraemia

Figures & data

Table 1. Patient and clinical characteristics of 303 patients with Staphylococcus aureus bacteraemia.

Age, years, n (%)
<60	90 (30)
60–69	55 (18)
70–79	74 (24)
≥80	84 (28)
Male sex, n (%)	186 (61)
Female sex, n (%)	117 (39)
CCI
0	69 (23)
1–2	123 (41)
≥3	111 (36)
Malignancy, n (%)	64 (21)
Diabetes mellitus, n (%)	80 (26)
Immunosuppression, n (%)	68 (22)
Renal failure, n (%)	30 (10)
Heart failure, n (%)	36 (12)
Chronic pulmonary disease, n (%)	40 (13)
Acquisition, n (%)
Community-acquired	89 (29)
Hospital-acquired	84 (28)
Healthcare-associated	130 (43)
Primary focus of infection, n (%)
Unknown	96 (32)
Skin and soft tissue	67 (22)
Urinary tract	22 (7)
Respiratory tract	19 (6)
Intravascular catheter^a	73 (24)
Surgical site	21 (7)
Other foci	5 (2)
Secondary foci, n (%)
Osteomyelitis and septic arthritis	81 (27)
Deep-seated abscess	53 (18)
Endocarditis	14 (5)
Other manifestations	17 (6)
Sepsis, n (%)	237 (78)
Severe sepsis and septic shock, n (%)	66 (22)

CCI: Charlson comorbidity index.

^aIncludes both peripheral and central intravascular catheters.

Table 2. All-cause mortality and infection-related mortality in 303 patients with Staphylococcus aureus bacteraemia.

	Mortality all-cause		Mortality infection-related
Days	n	%	n	%
30	63	20.8	56	18.4
90	80	26.7	60	19.8
180	94	31.0	62	20.4
365	110	36.3	63	20.8

Table 3. Predictors of 1-year all-cause mortality in 303 patients with Staphylococcus aureus bacteraemia.

	Univariate analysis			Multivariable analysis
	OR	95% CI	p value	OR	95% CI	p value
Age, years
<60	1.0	Reference		1.0	Reference
60–69	1.6	0.7–3.6	.30	1.4	0.6–3.6	.48
70–79	4.0	2.0–8.3	<.001	3.9	1.7–9.1	.001
≥80	7.0	3.5–14.2	<.001	6.5	2.9–14.6	<.001
Female vs male	1.2		.5
CCI
0	1.0	Reference		1.0	Reference
1–2	3.3	1.4–7.5	.005	2.2	0.9–5.5	.09
≥3	10.8	4.7–24.7	<.001	6.9	2.7–17.3	<.001
Acquisition
Community-acquired	1.0	Reference		Reference
Hospital-acquired	2.4	1.2–4.9	.01	1.6	0.7–3.6	.25
Healthcare-associated	4.6	2.4–8.7	<.001	2.3	1.1–4.9	.03
Severity
Sepsis	1.0	Reference
Severe sepsis/septic shock	3.4	1.9–5.9	<.001	3.6	1.8–7.1	<.001
Timing of antibiotics^a	0.9		.57
≥48 vs <48 h

Univariate and multivariable logistic regression analysis.

CCI: Charlson comorbidity index; OR: Odds ratio; CI: Confidence interval.

^aFrom debut of symptoms.

Table 4. Predictors of one-year infection-related mortality in 256 patients with Staphylococcal aureus bacteraemia.

	Univariate analysis			Multivariable analysis
	OR	95% CI	p value	OR	95% CI	p value
Age, years
<60	1.0	Reference		1.0	Reference
60–69	2.5	0.8–8.4	.14	3.1	0.8–12.6	.11
70–79	6.6	2.3–19.0	.001	7.9	2.3–27.3	.001
≥80	14.1	5.1–39.3	<.001	19.3	5.7–65.5	<.001
Female vs male	1.2		.1
CCI
0	1.0	Reference		1.0	Reference
1–2	3.1	1.1–8.7	.03	1.9	0.6–6.5	.29
≥3	9.6	3.5–26.2	<.001	5.8	1.7–20.0	.006
Acquisition
Community-acquired	1.0	Reference		Reference
Hospital-acquired	2.0	0.8–4.8	.12	1.3	0.4–3.7	.67
Healthcare-associated	4.3	2.0–9.2	<.001	1.7	0.6–4.4	.31
Severity
Sepsis	1.0	Reference
Severe sepsis/septic shock	7.2	3.8–13.7	<.001	8.8	3.9–19.8	<.001
Timing of antibiotics^a	1.1		.86
≥48 vs <48 h

Univariate and multivariable logistic regression analysis.

CCI: Charlson comorbidity index; OR: Odds ratio; CI: Confidence interval.

^aFrom debut of symptoms.