Antibiotic switch after treatment with UTI antibiotics in male patients

Figures & data

Table 1. Total UTI antibiotic prescriptions to men ≥16 years in Norway 2008–2018.

			Age	DDD
Antibiotic	Prescriptions	Patients	Mean (SD)	Median (IQR)
Cotrimoxazole	308,358	155,794	61.6 (17.7)	7.5 (5.0–10.0)
Cefalexin	88,298	60,419	53.4 (19.4)	5.0 (5.0–10.0)
Fluoroquinolones	468,111	238,515	59.9 (17.8)	10.0 (5.0–10.0)
Nitrofurantoin	93,605	37,771	70.4 (15.5)	6.3 (6.3–12.5)
Pivmecillinam	377,036	174,360	67.3 (17.4)	10.0 (6.7–13.3)
Trimethoprim	180,470	84,241	68.8 (17.1)	5.6 (5.3–7.5)
Total	1,515,878	476,423	63.4 (18.1)	10.0 (5.6–10.0)

Figure 1. Yearly prescriptions of the different UTI antibiotics per 1000 male inhabitants in Norway 2008–2018. Population statistics based on male inhabitants ≥16 years of age, collected by Statistics Norway (SSB).

Figure 2. Proportion (%) of prescriptions of UTI antibiotic resulting in antibiotic switch by days after initial treatment.

Table 2. Multivariate logistic analysis showing factors associated with antibiotic switch within 14 days after initial prescription.

	Total initial treatments	Antibiotic switch (%) within 14 days	Crude OR [95 %]	Adjusted OR [95% CI]^a
Total prescriptions	726,096	49,531 (6.8%)
Initial antibiotic
Cotrimoxazole	141,336	7824 (5.5%)	1 [reference]	1 [reference]
Cefalexin	60,480	878 (1.5%)	0.25 [0.23–0.27]	0.27 [0.26–0.30]
Fluoroquinolones	225,439	5170 (2.3%)	0.39 [0.38–0.41]	0.40 [0.39–0.42]
Nitrofurantoin	19,827	2106 (10.6%)	2.04 [1.93–2.15]	1.98 [1.88–2.09]
Pivmecillinam	206,814	25,759 (12.5%)	2.52 [2.45–2.59]	2.46 [2.39–2.53]
Trimethoprim	72,200	7794 (10.8%)	2.12 [2.05–2.20]	2.13 [2.05–2.21]
DDD
7 days or less	302,087	21,811 (7.2%)	1 [reference]	1 [reference]
8–14 days	424,009	27,720 (6.5%)	0.90 [0.88–0.92]	1.06 [1.04–1.08]
Patient age (mean)	61.3	66.4
16–49 years old	191,908	7370 (3.8%)	1 [reference]	1 [reference]
50–64 years old	173,156	11,791 (6.8%)	1.86 [1.80–1.92]	1.68 [1.63–1.73]
65–84 years old	281,120	23,711 (8.4%)	2.37 [2.30–2.44]	1.80 [1.75–1.85]
>85 years old	79,912	6659 (8.3%)	2.33 [2.25–2.41]	1.49 [1.44–1.55]
Risk factors
Year of prescription			1.02 [1.01–1.02]	1.001 [0.998–1.004]

^a Adjusted odds ratios are adjusted for antibiotic group, age group, DDD and year of prescription.