Covid-19 in kidney transplant recipients: a systematic review of the case series available three months into the pandemic

Figures & data

Figure 1. PRISMA flow chart.

Table 1. The reports included in the analysis.

Abrishami et al. [9]	12 patients	Hospitalized	Shahid Beheshti University of Medical Sciences, Tehran, Iran
Akalin et al. [10]	36 patients	Hospitalized and outpatient	Montefiore Medical Centre, Bronx, NY, USA
Alberici et al. [11]	20 patients	Hospitalized	University of Brescia, Brescia, Italy
Banerjee et al. [12]	7 patients	Hospitalized and outpatient	St. George’s University Hospital, National Health Service Foundation Trust, London, UK
Fernández-Ruiz et al. [13]	8 patients	Hospitalized	Instituto de Investigación Sanitaria Hospital ‘12 de Octubre’, Madrid, Spain
Columbia University Kidney Transplant Program [14]	15 patients	Hospitalized	Columbia University Irving Medical Centre, NY, USA
Husain et al. [15]	22 patients	Hospitalized and outpatient	Columbia University Irving Medical Centre, NY, USA
Montagud-Marrahi et al. [16]	33 patients	Hospitalized	Hospital Clinic, Barcelona, Spain
Nair et al. [17]	10 patients	Hospitalized	Northwell Health, Manhasset, NY, USA
Trujillo et al. [18]	26 patients	Hospitalized	Instituto de Investigación Sanitaria Hospital ‘12 de Octubre’, Madrid, Spain
Zhang et al. [19]	5 patients	Hospitalized	Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Zhu et al. [20]	10 patients	Hospitalized	Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Table 2. Clinical characteristics, findings at presentation, treatment and outcome of kidney transplant recipients with COVID-19.

Age (median, range) (N = 87)	55 (21–80)
Male (N = 204)	150/204 (74)
Deceased donor	81/102 (79)
First year after transplant	9/99 (9)
Comorbidities
Hypertension	136/156 (87)
Diabetes	56/156 (36)
Cardiovascular disease	16/134 (13)
COPD	3/134 (2.4)
Smoking	13/122 (11)
Symptoms at admission
Fever	130/171 (76)
Cough	109/171 (64)
Dyspnoea	74/171 (43)
Myalgia	36/171 (21)
Diarrhoea	36/171 (21)
Chest radiographic findings	112/149 (75)
Immunosuppression
Tacrolimus	183/204 (92)
MMF/MPA	154/204 (75)
Corticosteroids	157/204 (81)
mTOR inhibitors	28/204 (15)
Azathioprine	4/204 (2)
Belatacept	9/204 (2)
Treatment
Tacrolimus tapering	25/168 (15)
Tacrolimus withdrawal	65/168 (39)
Antimetabolite withdrawal	132/137 (96)
Hidroxycloroquine	137 /182(75)
Antivirals	108/182 (59)
IV immunoglobulins	18/182 (10)
Tocilizumab	26/182 (14)
Outcome
Dead	43/204 (21)
Discharged	63/204 (31)
In-hospital	97/204 (48)

Data are presented as the number/total number of available observations (percent) unless otherwise stated.

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