Successful Treatment of Interdigitating Dendritic Cell Sarcoma Presenting as Multiple Parotid Tumors

Figures & data

Figure 1. Contrast-enhanced CT findings at first visit and MRI findings 3 months after first visit. Contrast-enhanced CT at first visit showed one tumor in the upper end (A, arrowhead) and two tumors in the lower end (B, arrowhead) of parotid gland. MRI findings 3 months after the first visit showed enlarged tumors in axial section of T1 weighted intensity (C,D) and coronal section of T2 weighted intensity (E,F). Arrowheads indicate the tumors in the upper end (C,E) and the lower end (D,F) of parotid gland and superior deep lateral cervical lymph node (F).

Figure 2. Intraoperative finding and resected specimen. Arrowheads indicate the main trunk of the facial nerve at the cross point (A). The upper end of tumor (white dotted circle) invaded the zygomatic branch of facial nerve. The surgical specimens were whitish in color (B).

Figure 3. Microscopic finding of resected tumor. (A) Hematoxylin and Eosin (HE) stained finding in low power field. (B) HE stained finding in high power field. (C) S-100 immunostained finding. (D) Langerin immunostained finding. (E) CD21 immunostained finding.

Table 1. Reported cases of IDCS of the parotid gland.

Authors	Age/Sex	Site	Treatment	Prognosis F/U period
Barwell et al. [6]	51/F	Parotid	Surgery	NED 24M
Sharma et al. [7]	73/M	Parotid neck LN	Surgery + PORT	NED 15M
Efune et al. [8]	69/M	Parotid	Surgery + PORT	NED 12M
Present case	82/F	Parotid neck LN	Surgery + PORT	NED 36M

LN: lymph node; PORT: postoperative radiotherapy; M: months; NED: no evidence of disease; F/U: follow-up.

Barwell N, Howatson R, Jackson R, et al. Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection. J Clin Pathol. 2004;57:87–89.

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Sharma M, Ahsan F, Ah-See KW, et al. Interdigitating dendritic cell sarcoma of the parotid gland. J Laryngol Otol. 2006;120:244–246.

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Efune G, Sumer BD, Sarode VR, et al. Interdigitating dendritic cell sarcoma of the parotid gland: case report and literature review. Am J Otolaryngol. 2009;30:264–268.

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