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Mito Communications

Analysis of mitochondrial DNA sequence and copy number variation across five high-altitude species and their low-altitude relatives

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Pages 847-851 | Received 02 Feb 2018, Accepted 08 Jul 2018, Published online: 27 Aug 2018

Figures & data

Figure 1. Characteristics and phylogenetic analysis of mitogenome in five high-altitude species and their low-altitude relatives. (a) Detailed information of animals and geographical locations. b. Base content of mitochondrial genome across five species. c. Neighbor joining tree of five species, based on complete mtDNA sequences (Accession numbers: MG837547-MG837556); red branches denote high-altitude animals, and blue branches denote low-altitude animals.

Figure 1. Characteristics and phylogenetic analysis of mitogenome in five high-altitude species and their low-altitude relatives. (a) Detailed information of animals and geographical locations. b. Base content of mitochondrial genome across five species. c. Neighbor joining tree of five species, based on complete mtDNA sequences (Accession numbers: MG837547-MG837556); red branches denote high-altitude animals, and blue branches denote low-altitude animals.

Table 1. Genetic diversity analysis of the mtDNA D-loop region between high-altitude (from Tibet) and low-altitude animals (mostly from Sichuan basin).

Figure 2. mtDNA copy number analysis of four tissues across five species, and a heatmap of mtDNA copy number ratio between low- and high-altitude animals (n = 3/group) in those four tissues. Student’s t-test, *p < 0.05, **p < 0.01. Colored entries represent the log2 mtDNA copy number ratio between low-altitude and high-altitude animals. The significant value was regarded as 1.5.

Figure 2. mtDNA copy number analysis of four tissues across five species, and a heatmap of mtDNA copy number ratio between low- and high-altitude animals (n = 3/group) in those four tissues. Student’s t-test, *p < 0.05, **p < 0.01. Colored entries represent the log2 mtDNA copy number ratio between low-altitude and high-altitude animals. The significant value was regarded as 1.5.
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