Figures & data
Figure 1. Identification of mitochondria-related action targets of quercetin. (A) Volcano plot of differentially expressed genes (DEGs) from melanoma B16-F1 cells treated with quercetin versus controls. DEGs are designated in red (up-regulation (up)) and blue (down-regulation (down)), having an FDR of less than 0.05. (B) Heat map of 110 DEGs. (C–F) The GO analysis (biological process, molecular function, and cellar component) and KEGG enrichment of DEGs. According to the p value, the top 20 pathways were selected to draw bubble charts. (G) The PPI network constructed for DEGs. (H) Heat map of mitochondria-related action targets of quercetin from RNA-seq.
Figure 2. Assessment of mitochondria-related action targets of quercetin in melanoma. (A–F) Molecular docking of quercetin with BTG2, CP, LRIG1, CYP1A1, GBP2, and MBNL1, separately. (G) The expression of mitochondria-related action targets of quercetin. (H) Survival analysis of mitochondria-related action targets of quercetin.
Supplemental Material
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The RNA-seq data that support the findings of this study are openly available in NCBI at https://www.ncbi.nlm.nih.gov/sra/PRJNA952519. The associated BioProject accession number is PRJNA952519; the Bio-Sample numbers are SAMN34074959, SAMN34074960, SAMN34074961, SAMN34074962, SAMN34074963, and SAMN34074964; the SRA accession numbers are SRR24071997, SRR24071996, SRR24071995, SRR24071994, SRR24071993, and SRR24071992.