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Innovation in Biomedical Science and Engineering

Improving hemodynamics of cardiovascular system under a novel intraventricular assist device support via modeling and simulations

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Figures & data

Figure 1. Schematic of a typical intra-ventricular assist device.

Figure 1. Schematic of a typical intra-ventricular assist device.

Figure 2. Illustration of the pulsatile rhythm of the left ventricle and the iVAD.

Figure 2. Illustration of the pulsatile rhythm of the left ventricle and the iVAD.

Figure 3. The cardiovascular circuit model.

Figure 3. The cardiovascular circuit model.

Figure 4. Graphs indicating the elastance function: (a) Normalized elastance; (b) Healthy heart elastance.

Figure 4. Graphs indicating the elastance function: (a) Normalized elastance; (b) Healthy heart elastance.

Table 1. Variables in the cardiovascular system model.

Table 2. Model parameters.

Figure 5. Schematic of a mock cardiovascular system.

Figure 5. Schematic of a mock cardiovascular system.

Figure 6. The elastance curves of the pump: (a) Ep(t) under different drive pressure; (b) Epn(tn).

Figure 6. The elastance curves of the pump: (a) Ep(t) under different drive pressure; (b) Epn(tn).

Figure 7. The Ep(t) and Epn(tn) of different afterload at 75bpm and 145 mmHg drive pressure: (a) Ep(t), iVAD’s elastance; (b) Epn(tn), the normalized elastance.

Figure 7. The Ep(t) and Epn(tn) of different afterload at 75bpm and 145 mmHg drive pressure: (a) Ep(t), iVAD’s elastance; (b) Epn(tn), the normalized elastance.

Figure 8. Ep(t), Epn(tn) curves of different heart rates: (a) Ep(t), iVAD’s elastance, (b) Epn(tn), normalized elastance.

Figure 8. Ep(t), Epn(tn) curves of different heart rates: (a) Ep(t), iVAD’s elastance, (b) Epn(tn), normalized elastance.

Figure 9. Epn(tn) showing 75 bpm and 145 mmHg curves: (a) Epn(tn); (b) fitting curve.

Figure 9. Epn(tn) showing 75 bpm and 145 mmHg curves: (a) Epn(tn); (b) fitting curve.

Figure 10. Epmax, Epmin curves of drive pressure.

Figure 10. Epmax, Epmin curves of drive pressure.

Figure 11. The cardiovascular cycle model combined with iVAD.

Figure 11. The cardiovascular cycle model combined with iVAD.

Figure 12. Hemodynamic parameters of the 4 categories of heart failure: (a) Pressure, (b) Aortic flow, (c) Pressure-volume loops.

Figure 12. Hemodynamic parameters of the 4 categories of heart failure: (a) Pressure, (b) Aortic flow, (c) Pressure-volume loops.

Figure 13. Hemodynamic parameters after iVAD assistance for the 4 categories of heart failure: (a) Pressure, (b) Aortic flow, (c) Pressure-volume loops.

Figure 13. Hemodynamic parameters after iVAD assistance for the 4 categories of heart failure: (a) Pressure, (b) Aortic flow, (c) Pressure-volume loops.

Table 3. Comparison of the simulation results of iVAD power off with iVAD power on.