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Mitochondrial DNA Part A
DNA Mapping, Sequencing, and Analysis
Volume 28, 2017 - Issue 6
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Research Article

High occurrence of length heteroplasmy in domestic Bactrian camel (Camelus bactrianus)

Xiaohong HeThe Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China; ;CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China;
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Xiaofei ChenThe Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China; ;CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China;
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Wenbin ZhangBactrian Camels Institute of Alxa League, Inner Mongolia Autonomous Region, China;
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Yabin PuThe Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China; ;CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China;
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Shen SongThe Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China; ;CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China;
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Jianlin HanCAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China; ;International Livestock Research Institute (ILRI), Nairobi, Kenya
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Kunzhe DongThe Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China; ;CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China;
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Qianjun ZhaoThe Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China; ;CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China;
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Weijun GuanThe Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China; ;CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China;
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Yuehui MaThe Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China; ;CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China; Correspondence[email protected] [email protected]
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Lin JiangThe Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China; ;CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Science (CAAS), Beijing, China; Correspondence[email protected] [email protected]
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Pages 851-854 | Received 13 Apr 2016, Accepted 31 May 2016, Published online: 10 Dec 2016
 
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Abstract

Heteroplasmy is the presence of more than one mitochondrial DNA (mtDNA) variant within a cell, tissue, or individual. In this study, sequence variation was investigated in the control region (CR) of mitochondrial DNA (mtDNA) from 135 individuals belonging to five primary domestic Bactrian camel breeds in China and Mongolia. Due to variation of the repeat unit G(T/C)(AC)n, length heteroplasmy was detected within each camel by direct sequencing and fragment analysis. A high occurrence of mtDNA heteroplasmy, up to 100 percentages was observed in five camel populations. Our study provides the first evidence of extensive length heteroplasmy in Bactrian camels.

Disclosure statement

The authors declare that they have no competing interests.

Funding information

This work was supported by the Agricultural Science and Technology Innovation Program of China to YM (Grant No. ASTIP-IAS01), Special Fund for Basic Scientific Research of Institute of Animal Science, Chinese Academy of Agricultural Sciences to XH (Grant No. 2012cj-6) and Chinese Domestic Animal Germplasm Resources Infrastructure to YM. LJ was supported by the Elite Youth Program in Chinese Academy of Agricultural Sciences.

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