Agomelatine overdose and related toxicity

Figures & data

Figure 1. Chemical structure of melatonin (top) and agomelatine (bottom).

Table 1. Demographic and poisoning information from agomelatine-related calls to VPIC.

Demographic and poisoning information	Calls (%)
Call types
Total	99
Intentional overdose	72 (73%)
Therapeutic error	15 (15%)
Accidental ingestion	11 (11%)
Misuse	1 (1%)
Callers
Doctors	54 (55%)
Family/friends	21 (21%)
Nurses	9 (9%)
Self	9 (9%)
Others (e.g. ambulance, counsellor, pharmacists)	6 (6%)
Handling
In hospital	63 (64%)
No action required	22 (22%)
Hospital referral	13 (13%)
Referral to general practitioner	1 (1%)
Intentional overdose
Total agomelatine overdose-related calls	72
Females	44 (61%)
Males	28 (39%)
Adults (20–74)	56 (78%)
Adolescents (15–19)	13 (18%)
Elderly (≥75)	1 (1%)
Not reported	2 (3%)
Poison severity score
None	22 (31%)
Minor	36 (50%)
Moderate	11 (15%)
Severe	3 (4%)
Common co-ingestants
Total polydrug overdoses	56
Antidepressants other than agomelatine	28 (50.0%)
Benzodiazepines	24 (43%)
Antipsychotics	14 (25%)
Antiepileptics	8 (14%)
Symptoms (sole agomelatine intentional overdose)
Total calls	16
Asymptomatic	7 (44%)
Drowsiness	5 (31%)
Dizziness	1 (6%)
Nausea	1 (6%)
Symptoms unknown	3 (19%)

Figure 2. Onset of symptoms in cases of intentional overdose.