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Toxicology Communications Volume 6, 2022 - Issue 1
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Case Report

Propafenone and valsartan overdose with cardiovascular deterioration managed with lipid emulsion and high dose insulin: a case report

Connie H. Yoona Department of Pharmacy Services, OhioHealth Riverside Methodist Hospital, Columbus, OH, USAORCID Iconhttps://orcid.org/0000-0001-6176-9305
ORCID Icon,
Natalie I. Rineb Central Ohio Poison Center, Nationwide Children’s Hospital, Columbus, OH, USAORCID Iconhttps://orcid.org/0000-0003-1912-0697
ORCID Icon,
Adam Smitha Department of Pharmacy Services, OhioHealth Riverside Methodist Hospital, Columbus, OH, USAORCID Iconhttps://orcid.org/0000-0003-4461-3397
ORCID Icon &
Marcel J. Casavantb Central Ohio Poison Center, Nationwide Children’s Hospital, Columbus, OH, USA;c Colleges of Medicine and Pharmacy, Ohio State University, Columbus, OH, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8513-4144
ORCID Icon
Pages 62-65 | Published online: 04 May 2022

Figures & data

Figure 1. Case timeline.

BP, blood pressure; EKG, electrocardiogram; HIET, hyperinsulinemic euglycemic therapy; ILE, intravenous lipid emulsion; mEq, milliequivalents; ms, milliseconds; NaHCO3, sodium bicarbonate; NS, normal saline; ROSC, return of spontaneous circulation; VT, ventricular tachycardia.

Figure 1. Case timeline.BP, blood pressure; EKG, electrocardiogram; HIET, hyperinsulinemic euglycemic therapy; ILE, intravenous lipid emulsion; mEq, milliequivalents; ms, milliseconds; NaHCO3, sodium bicarbonate; NS, normal saline; ROSC, return of spontaneous circulation; VT, ventricular tachycardia.

Figure 2. Electrocardiogram measurements with administration of key therapies.

EKG, electrocardiogram; HIET, hyperinsulinemic-euglycemic therapy.

Figure 2. Electrocardiogram measurements with administration of key therapies.EKG, electrocardiogram; HIET, hyperinsulinemic-euglycemic therapy.

Figure 3. Hemodynamic parameters during HIET.

**Heart rate and blood pressure from ED arrival to ∼36 h after admission.

Figure 3. Hemodynamic parameters during HIET.**Heart rate and blood pressure from ED arrival to ∼36 h after admission.

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