Analysis of Centruroides (Scorpion) Immune F(ab’)₂ (Equine) administration by slow intravenous push

Figures & data

Table 1. Scorpion envenomation severity grading scale.

Grade	Clinical Features
I	Local pain or local paresthesia
II	Pain or paresthesia remote from the envenomation site
III	Cranial nerve dysfunction OR somatic skeletal muscle dysfunction
IV	Cranial nerve dysfunction AND somatic skeletal muscle dysfunction

Table 2. Rate of adjunctive medication use.

Medication/Medication Class	n (%)
Benzodiazepines	5 (20%)
Opioids	11 (44%)
Ibuprofen	6 (24%)
Epinephrine	1 (4%)
Glycopyrrolate	5 (20%)
Ondansetron	5 (20%)
Diphenhydramine	2 (8%)
Famotidine	1 (4%)

Table 3. Grade of envenomation comparison.

Variables	Envenomation Grade		p-value^a
	III (n = 7)	IV (n = 17)
Time to resolution of symptoms (minutes), Median, IQR^b	91 (IQR: 76.5–103)	68 (IQR: 60–114)	0.65
Initial number of vials administered	1 (100%)	1 (100%)	>0.99
Total number of vials administered, Median, Range	1 (1–2)	1 (1–3)	0.85
Length of stay (days, %)	0 (100%)	0 (100%)	>0.99
Number of serious administration-related adverse events^c	0	1	>0.99
Discharge from ED (n, %)^d	7 (100%)	16 (94%)	>0.99

^a Wilcoxon rank-sum test for continuous and chi-square test for count variables.

^b Interquartile range.

^c See definitions in primary outcome.

^d One patient was excluded from this table for receiving antivenom without an envenomation grade and was ultimately diagnosed with a toxic ingestion instead of a scorpion envenomation.