Buprenorphine/naloxone induction for treatment of acute on chronic pain using a micro-dosing regimen: A case report

Figures & data

Table 1. Buprenorphine/naloxone micro-dosing titration schedule.^a

Day	Buprenorphine dose	Buprenorphine/naloxone strength to use
1	0.25 mg sublingual daily	Buprenorphine 2 mg/naloxone 0.5 mg
2	0.25 mg sublingual twice daily	Buprenorphine 2 mg/naloxone 0.5 mg
3	0.5 mg sublanguage twice daily	Buprenorphine 2 mg/naloxone 0.5 mg
4	1 mg sublingual twice daily	Buprenorphine 2 mg/naloxone 0.5 mg
5	2 mg sublingual twice daily	Buprenorphine 2 mg/naloxone 0.5 mg
6	4 mg sublingual twice daily	Buprenorphine 2 mg/naloxone 0.5 mg
7	12 mg sublingual daily	Buprenorphine 2 mg/naloxone 0.5 mg

^aStarting on day 8, continue buprenorphine/naloxone 12 mg/3 mg (one tab) sublingual once daily.