A preliminary study of the genes related to aggression and insensitivity to pain in autism spectrum disorders

Figures & data

Table 1. Clinical and socio-demographic features of ASD patients.

Patients	Age (months)	Gender (M/F)	CARS score	Additional clinical findings	ADSI	Aggression	Insensitivity to pain
P10-101	72	Male	32	ADHD	Normal	Negative	Negative
P10-102	27	Male	31	ID	Abnormal	Negative	Negative
P13-101	36	Female	43	ID	Abnormal	Positive	Positive
P17-101	72	Male	41.5	ID	Abnormal	Positive	Positive
P18-101	60	Male	33.5	ID, ADHD	Abnormal	Positive	Negative
P19-101	41	Male	32	None	Normal	Negative	Negative
P20-101	55	Male	30	None	Normal	Negative	Negative
P21-101	80	Male	30	None	Normal	Negative	Negative
P22-101	60	Male	32	ID	Suspicious	Negative	Negative
P23-101	41	Male	32.5	ID	Suspicious	Positive	Negative
P24-101	96	Male	31.5	ID, ADHD	Abnormal	Positive	Negative
P25-101	72	Male	30	ID	Suspicious	Negative	Negative
P26-101	72	Female	41.5	ID, ADHD	Abnormal	Positive	Negative
P28-101	29	Male	40	ID	Abnormal	Positive	Positive
P29-101	36	Male	32.5	ID	Suspicious	Negative	Negative
P30-101	31	Male	31.5	ID	Suspicious	Negative	Negative
P31-101	60	Male	37.5	ID	Suspicious	Positive	Negative
P32-101	48	Male	35	ID	Abnormal	Negative	Negative
P33-101	24	Male	31	ID	Suspicious	Positive	Negative
P33-102	24	Female	38	ID, Agitation	Abnormal	Positive	Positive
P34-101	108	Male	39.5	ID, Agitation	Abnormal	Positive	Positive
P34-102	108	Female	32	None	Normal	Negative	Negative

Figure 1. (A) OPRL1 gene expression between the groups (p < .001), (B) TACR1 gene expression between the groups (p < .001), (C) HTR1E gene expression between the groups (p = .007).

Figure 2. Displaying the scatterplot of the relationship between the OPRL1, TACR1, and HTR1E genes in the ASD group.

Figure 3. Displaying the scatterplot of the relationship between CARS scores and the OPRL1, TACR1, and HTR1E genes in the ASD group.