The role of affective temperaments and chronotype in pharmacotherapy response in patients with obsessive-compulsive disorder

Figures & data

Table 1. Sociodemographic characteristics of sample.

	Patient group n = 76	Control group n = 55
Age
Female	34.90 ± 10.84	33.78 ± 9.20
Male	27.96 ± 10.29	35.17 ± 9.20
Total	32.53 ± 11.09	34.36 ± 9.93
Gender n (%)
Female	50 (65.8)	32 (58.2)
Male	26 (34.2)	23 (41.8)
Marital Status n (%)
Single	43 (56.6)	25 (45.5)
Married	26 (34.2)	29 (52.7)
Other	7 (9.2)	1 (1.8)

Note: Percentages are shown in parentheses.

Table 2. Differences between the study groups in terms of affective temperament characteristics.

Scale	Group	Mean rank	U	z	p
Depressive Temperament	Patient	74.71	1428.000	−3.099	. 002
	Control	53.96
Cyclothymic Temperament	Patient	79.47	1066.000	−4.787	. 000
	Control	47.38
Hyperthymic Temperament	Patient	65.84	2078.000	−0.056	. 955
	Control	66.22
Irritable Temperament	Patient	75.20	1291.000	−3.278	. 001
	Control	53.29
Anxious Temperament	Control	79.04	1099.000	−4.631	. 000
	Patient	47.98

Table 3. Differences between the patients in remission and not in remission in terms of affective temperament characteristics, comorbid depression, and anxiety.

Scale	Group	Mean rank	U	z	p
Depression	In remission	23.96	272.000	−4.145	. 000
	Not in remission	46.06
Anxiety	In remission	23.54	261.000	−4.264	. 000
	Not in remission	46.28
Depressive Temperament	In remission	25.98	324.500	−3.573	. 000
	Not in remission	45.01
Cyclothymic Temperament	In remission	30.06	430.500	−2.412	. 016
	Not in remission	42.89
Hyperthymic Temperament	In remission	46.79	434.500	−2.268	. 018
	Not in remission	34.19
Irritable Temperament	In remission	30.44	440.500	−2.304	. 021
	Not in remission	42.69
Anxious Temperament	In remission	27.94	375.500	−3.010	. 003
	Not in remission	43.99

Table 4. Comparison of the patients and the controls in terms of dominant temperament.

Dominant temperament	The patient group		The control group		Test	p
	n	%	n	%
Depressive temperament	16	21.1	3	5.5	df = 1, χ^2 = 6.261	. 012
Cyclothymic temperament	2	2.6	0	0	Fisher’s exact test	.509
Hyperthymic temperament	–	–	–	–	–	–
Irritable temperament	4	5.3	1	1.8	Fisher’s exact test	.398
Anxious temperament	11	14.4	–	–	df = 1, χ^2 = 8.690	. 003

Note: Fisher’s exact test was used for expected cell frequencies is 5 or less.

Table 5. The chronobiologic features between the OCD patients and the healthy controls.

Chronotype	Patient group	Healthy group	χ^2 (df = 2)	p
Morningness	9 (11.8)	15 (27.3)	χ^2 = 5.465	.06
Intermediate	50 (65.8)	32 (58.2)
Eveningness	17 (22.4)	8 (14.5)

Note: Percentages are shown in parentheses.

Table 6. Results of multiple linear regression for Y-BOCS predictors.

		B	Beta	t	p
Model 1	(Constant)	7.820		1.710	.091
	Age	0.253	0.281	2.417	.018
	Gender	1.790	0.086	0.735	.464
Model 2	(Constant)	10.555		1.949	.055
	Age	0.137	0.153	1.321	.191
	Gender	−0.275	−0.013	−0.119	.906
	Depressive Temperament	0.180	0.084	0.461	.646
	Cyclothymic Temperament	0.722	0.337	2.213	.030
	Hyperthymic Temperament	−0.600	−0.245	−2.022	.047
	Irritable Temperament	−0.019	−0.007	−0.060	.953
	Anxious Temperament	0.098	0.060	0.376	.708

Notes: Dependent variable: YBOC-S scores. R² = 0.333, p < .001.