Comparison of the effects of sertraline and agomelatine on sleep quality, sexual functioning and metabolic parameters in patients with major depressive disorder

Figures & data

Table 1. Comparison of the demographical and clinical data of patients using sertraline or agomelatine.

Variable	Sertraline (n = 30)	Agomelatine (n = 30)	p value
Age (years)	35.16 ± 12.08 (21–63)	34.16 ± 8.84 (20–61)	.716
Sex (female:male)	21:9	23:7	.559
Marital status			.602
Married	16	18
Not married	14	12
Occupation			.196
Employed	17	12
Not employed	13	18
Education (years)	7.73 ± 4.66	7.96 ± 4.49	.844
Past depression episodes	0.66 ± 0.71	0.90 ± 0.92	.278

Note: Values are presented as mean ± standard deviation (range) or number only.

Figure 1. The changes in the mean PSQI scores of the study groups in the follow-up period. ⁺The decline of PSQI scores in sertraline group throughout the follow-up period (effect size (η²) = 0.51). ⁺⁺The decline of PSQI scores in agomelatine group throughout the follow-up period (effect size (η²) = 0.56). ⁺⁺⁺The difference in decline of PSQI scores between study groups (effect size (η²) = 0.87).

Figure 2. The changes in the mean ASEX scores of the study groups in the follow-up period. ⁺The decline of ASEX scores in sertraline group throughout the follow-up period. ⁺⁺The decline of ASEX scores in agomelatine group throughout the follow-up period (effect size (η²) = 0.20). ⁺⁺⁺The difference in decline of ASEX scores between study groups.

Table 2. Comparison of the pre-treatment (time 0) metabolic parameters with the post-treatment (12th week) metabolic parameters in patients using sertraline or agomelatine.

	Sertraline			Agomelatine
	Pre-treatment	Post-treatment	p value	Pre-treatment	Post-treatment	p value
BMI	25.69 ± 4.93	26.49 ± 7.34	.485	24.62 ± 3.84	24.87 ± 3.97	.356
WC	84.11 ± 12.09	83.63 ± 11.30	.197	83.16 ± 10.15	83.70 ± 10.49	.907
SBP	114.10 ± 11.32	112.09 ± 9.61	.375	110.66 ± 9.8	112.33 ± 8.58	.362
DBP	78.16 ± 8.55	76.83 ± 7.93	.471	75.83 ± 8.71	73.66 ± 7.64	.202
FBG	86.5 ± 7.99	85.2 ± 10.03	.402	88.7 ± 10.52	89.2 ± 8.60	.753
AST	17.5 ± 3.66	19.06 ± 6.34	.391	17.73 ± 5.58	19.13 ± 5.07	.038^a
ALT	15.66 ± 6,84	16.03 ± 7.27	.779	16.03 ± 8.94	20.3 ± 10.93	.002^b
TC	178.1 ± 33.81	182.6 ± 38.76	.294	171.83 ± 24.75	170.50 ± 22.5	.606
TT	99.16 ± 44.95	97.26 ± 44.42	.762	112.03 ± 66.20	101.4 ± 53.84	.067
LDL	105.55 ± 28.84	121.76 ± 41.94	.010^c	107.2 ± 18.04	107.33 ± 32.91	.965
HDL	47.93 ± 8.52	45.96 ± 9.81	.071	42.2 ± 7.88	42.36 ± 9.11	.862
VLDL	19.26 ± 8.59	19.73 ± 8.55	.675	21.8 ± 12.66	20.13 ± 11.62	.051

Note: BMI: body mass index (kg/m²); WC: waist circumference (cm); SBP: systolic; DBP: diastolic blood pressure (mmHg); FBG: fasting blood glucose (mg/dL); ALT: alanine transaminase (IU/L); AST: aspartate transaminase (IU/L); TC: total cholesterol (mg/dL); TT: total triglycerides (mg/dL); LDL: low density lipoprotein (mg/dL); HDL: high density lipoprotein (mg/dL); VLDL: very low density lipoprotein (mg/dL).

^aeffect size (r²) : 0.32.

^beffect size (r²) : 0.23.

^ceffect size (r²) : 0.15.